{"id":68724,"date":"2026-04-27T10:58:52","date_gmt":"2026-04-27T02:58:52","guid":{"rendered":"http:\/\/111.62.156.167\/?chemical-product=n-nitrosonornicotine-n-%ce%b2-d-glucuronide-mixture-of-diastereomers-hydrate"},"modified":"2026-04-27T10:58:52","modified_gmt":"2026-04-27T02:58:52","slug":"n-nitrosonornicotine-n-%ce%b2-d-glucuronide-mixture-of-diastereomers-hydrate","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=n-nitrosonornicotine-n-%ce%b2-d-glucuronide-mixture-of-diastereomers-hydrate","title":{"rendered":"N\u2019-Nitrosonornicotine N-\u03b2-D-glucuronide (mixture of diastereomers) hydrate"},"content":{"rendered":"<p>\u4ea7\u54c1\u8bf4\u660e<br \/>\nN\u2019-\u4e9a\u785d\u57fa\u53bb\u7532\u70df\u78b1-N-\u03b2-D-\u8461\u8404\u7cd6\u919b\u9178\u82f7\uff08\u975e\u5bf9\u6620\u5f02\u6784\u4f53\u6df7\u5408\u7269\uff09\u6c34\u5408\u7269\u4ea7\u54c1\u8bf4\u660e\u4e66<br \/>\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027<br \/>\n\u672c\u54c1\u4e3aN\u2019-\u4e9a\u785d\u57fa\u53bb\u7532\u70df\u78b1\uff08NNN\uff09\u7684\u8461\u8404\u7cd6\u919b\u9178\u7ed3\u5408\u7269\uff0c\u5316\u5b66\u540d\u79f0N\u2019-Nitrosonornicotine N-\u03b2-D-glucuronide\uff0c\u662f\u70df\u8349\u7279\u6709\u4e9a\u785d\u80fa\uff08TSNA\uff09\u4ee3\u8c22\u7814\u7a76\u7684\u5173\u952e\u6807\u51c6\u54c1\u3002CAS\u53f7350508-25-7\uff0c\u5206\u5b50\u5f0fC15H19N3O7\u2022(H2O)x\uff0c\u5206\u5b50\u91cf\u56e0\u6c34\u5408\u7269\u542b\u91cf\u5dee\u5f02\u53ef\u80fd\u5b58\u5728\u6d6e\u52a8\u3002\u4ea7\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u56fa\u4f53\uff0c\u7eaf\u5ea6>96%\uff08HPLC\u9a8c\u8bc1\uff09\uff0c\u5305\u542b\u975e\u5bf9\u6620\u5f02\u6784\u4f53\u6df7\u5408\u7269\uff0c\u9002\u7528\u4e8e\u7cbe\u51c6\u4ee3\u8c22\u7269\u5b9a\u91cf\u5206\u6790\u3002<br \/>\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027<br \/>\n\u4f5c\u4e3aNNN\u7684\u4e3b\u8981\u2161\u76f8\u4ee3\u8c22\u4ea7\u7269\uff0c\u672c\u54c1\u901a\u8fc7\u8461\u8404\u7cd6\u919b\u9178\u8f6c\u79fb\u9176\uff08UGT\uff09\u50ac\u5316\u5f62\u6210\uff0c\u5728\u751f\u7269\u4f53\u5185\u53c2\u4e0e\u89e3\u6bd2\u4e0e\u6392\u6cc4\u8fc7\u7a0b\u3002\u5176\u5b58\u5728\u76f4\u63a5\u53cd\u6620NNN\u7684\u4ee3\u8c22\u6fc0\u6d3b\u6c34\u5e73\uff0c\u5bf9\u7814\u7a76\u70df\u8349\u81f4\u764c\u673a\u5236\u3001\u8bc4\u4f30\u4e2a\u4f53\u4ee3\u8c22\u5dee\u5f02\u53ca\u6bd2\u6027\u98ce\u9669\u5177\u6709\u6807\u5fd7\u6027\u610f\u4e49\u3002\u5f02\u6784\u4f53\u6df7\u5408\u7269\u7684\u7279\u6027\u53ef\u5168\u9762\u8986\u76d6\u5b9e\u9645\u751f\u7269\u6837\u672c\u4e2d\u7684\u4ee3\u8c22\u8c31\u3002<br \/>\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014<br \/>\n\u672c\u54c1\u4e13\u7528\u4e8e\u6bd2\u7406\u5b66\u4e0e\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u9886\u57df\uff1a<br \/>\n&#8211; \u4f5c\u4e3a\u5185\u6807\u6216\u6821\u51c6\u54c1\uff0c\u7528\u4e8eLC-MS\/MS\u6cd5\u68c0\u6d4b\u751f\u7269\u6837\u672c\uff08\u5c3f\u6db2\u3001\u8840\u6e05\uff09\u4e2d\u7684NNN\u4ee3\u8c22\u7269<br \/>\n&#8211; \u70df\u8349\u5236\u54c1\u98ce\u9669\u8bc4\u4f30\u4e2d\u4ee3\u8c22\u901a\u91cf\u7814\u7a76\u7684\u53c2\u7167\u7269\u8d28<br \/>\n&#8211; \u6784\u5efa\u4f53\u5916\u4ee3\u8c22\u6a21\u578b\uff08\u5982\u809d\u5fae\u7c92\u4f53\u5b9e\u9a8c\uff09\u7684\u5e95\u7269\u6216\u4ea7\u7269\u6807\u51c6<br \/>\n&#8211; \u81f4\u764c\u673a\u7406\u7814\u7a76\u4e2dDNA\u52a0\u5408\u7269\u5f62\u6210\u7684\u5173\u8054\u5206\u6790<br \/>\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae<br \/>\n\u50a8\u5b58\u4e8e-20\u2103\u907f\u5149\u5e72\u71e5\u73af\u5883\uff0c\u5f00\u5c01\u540e\u5efa\u8bae\u5206\u88c5\u4fdd\u5b58\u4ee5\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u4f7f\u7528\u65f6\u4ee5\u7532\u9187\u6216\u6c34\u6eb6\u89e3\uff08\u6eb6\u89e3\u5ea6>5 mg\/mL\uff09\uff0c\u73b0\u914d\u73b0\u7528\u3002\u9700\u6ce8\u610f\uff1a<br \/>\n&#8211; \u6c34\u5408\u7269\u5f62\u5f0f\u53ef\u80fd\u5bfc\u81f4\u5b9e\u9645\u79f0\u91cf\u6d53\u5ea6\u504f\u5dee\uff0c\u5efa\u8bae\u901a\u8fc7\u6c34\u5206\u6ef4\u5b9a\u6821\u6b63<br \/>\n&#8211; \u5f02\u6784\u4f53\u6bd4\u4f8b\u53ef\u80fd\u56e0\u6279\u6b21\u7565\u6709\u5dee\u5f02\uff0c\u5b9a\u91cf\u5206\u6790\u65f6\u5efa\u8bae\u914d\u5957\u4f7f\u7528\u540c\u6279\u6b21\u6807\u51c6\u66f2\u7ebf<br \/>\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f<br \/>\n\u901a\u8fc7HPLC-UV\/ELSD\u53cc\u7cfb\u7edf\u9a8c\u8bc1\u7eaf\u5ea6\uff0c\u6279\u53f7\u76f8\u5173COA\u53ef\u968f\u8d27\u63d0\u4f9b\u3002\u672c\u54c1\u5c5e\u6f5c\u5728\u81f4\u764c\u7269\uff0c\u64cd\u4f5c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\uff0c\u4f69\u6234\u9632\u6e17\u900f\u624b\u5957\u53ca\u62a4\u76ee\u955c\u3002\u5e9f\u5f03\u7269\u5e94\u6309\u5371\u9669\u5316\u5b66\u54c1\u5904\u7406\uff0c\u907f\u514d\u63a5\u89e6\u5f3a\u6c27\u5316\u5242\u3002\u6025\u6027\u6bd2\u6027\u6570\u636e\u53c2\u8003NNN\uff08LD50\u5927\u9f20\u53e3\u670d>500 mg\/kg\uff09\uff0c\u5177\u4f53\u6bd2\u7406\u5b66\u53c2\u6570\u5efa\u8bae\u67e5\u9605\u6700\u65b0\u6587\u732e\u3002<br \/>\n\uff08\u6ce8\uff1a\u5b9e\u9645\u5206\u5b50\u91cf\u9700\u6839\u636e\u6c34\u542b\u91cf\u8ba1\u7b97\uff0cx\u503c\u53c2\u89c1\u6279\u6b21\u5206\u6790\u8bc1\u4e66\uff09<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[31],"class_list":["post-68724","chemical-product","type-chemical-product","status-publish","hentry","product_category-31"],"acf":[],"taxonomy_info":{"product_category":[{"value":31,"label":"\u7cd6\u79d1\u5b66"}]},"featured_image_src_large":false,"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/68724","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=68724"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=68724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}