1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u54c1\u4e3a(1R,2R)-2-(2-\u4e59\u57fa\u82ef\u57fa)\u73af\u4e19\u70f7\u7fa7\u9178\uff08Cyclopropanecarboxylic acid, 2-(2-ethylphenyl)-, (1R,2R)-\uff09\uff0cCAS\u53f71808742-39-3\uff0c\u5206\u5b50\u5f0fC12H14O2\uff0c\u5206\u5b50\u91cf190.24\u3002\u8be5\u5316\u5408\u7269\u662f\u4e00\u79cd\u624b\u6027\u73af\u4e19\u70f7\u884d\u751f\u7269\uff0c\u7eaf\u5ea6>96%\uff0c\u5e38\u6e29\u4e0b\u5448\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u7c89\u672b\u3002\u5176\u7ed3\u6784\u4e2d\u542b\u6709\u4e00\u4e2a\u521a\u6027\u73af\u4e19\u70f7\u73af\u548c\u82b3\u9999\u65cf\u53d6\u4ee3\u57fa\uff0c\u5177\u6709\u663e\u8457\u7684\u7acb\u4f53\u9009\u62e9\u6027\u548c\u5316\u5b66\u7a33\u5b9a\u6027\uff0c\u9002\u5408\u4f5c\u4e3a\u624b\u6027\u5408\u6210\u780c\u5757\u6216\u751f\u7269\u6d3b\u6027\u5206\u5b50\u4e2d\u95f4\u4f53\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u8be5\u5316\u5408\u7269\u56e0\u5176\u72ec\u7279\u7684\u73af\u4e19\u70f7\u7ed3\u6784\u548c\u624b\u6027\u4e2d\u5fc3\uff0c\u5728\u836f\u7269\u5316\u5b66\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002\u73af\u4e19\u70f7\u7247\u6bb5\u53ef\u589e\u5f3a\u5206\u5b50\u521a\u6027\uff0c\u8c03\u8282\u8102\u6eb6\u6027\u548c\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u800c(1R,2R)-\u6784\u578b\u53ef\u80fd\u8d4b\u4e88\u5176\u7279\u5b9a\u7684\u751f\u7269\u6d3b\u6027\u3002\u7814\u7a76\u8868\u660e\uff0c\u7c7b\u4f3c\u7ed3\u6784\u5728\u6297\u708e\u3001\u6297\u80bf\u7624\u53ca\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u836f\u7269\u7814\u53d1\u4e2d\u8868\u73b0\u51fa\u6f5c\u5728\u6d3b\u6027\uff0c\u5c24\u5176\u4f5c\u4e3aGABAA\u53d7\u4f53\u8c03\u8282\u5242\u6216\u9176\u6291\u5236\u5242\u7684\u5019\u9009\u5206\u5b50\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u54c1\u4e3b\u8981\u7528\u4e8e\u533b\u836f\u7814\u53d1\u9886\u57df\uff0c\u5177\u4f53\u5305\u62ec\uff1a1\uff09\u4f5c\u4e3a\u624b\u6027\u4e2d\u95f4\u4f53\u7528\u4e8e\u4e0d\u5bf9\u79f0\u5408\u6210\uff1b2\uff09\u7528\u4e8e\u6784\u5efa\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u73af\u4e19\u70f7\u7c7b\u5316\u5408\u7269\u5e93\uff1b3\uff09\u5728\u836f\u7269\u5148\u5bfc\u5316\u5408\u7269\u4f18\u5316\u4e2d\uff0c\u7528\u4e8e\u6539\u5584\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002\u6b64\u5916\uff0c\u5728\u519c\u7528\u5316\u5b66\u54c1\u548c\u6750\u6599\u79d1\u5b66\u4e2d\u4e5f\u6709\u63a2\u7d22\u6027\u5e94\u7528\uff0c\u5982\u6db2\u6676\u6750\u6599\u7684\u624b\u6027\u6dfb\u52a0\u5242\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5bc6\u5c01\u4fdd\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u5149\u7167\u548c\u6e7f\u5ea6\u3002\u5f00\u5c01\u540e\u9700\u5145\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4ee5\u5ef6\u957f\u7a33\u5b9a\u6027\u3002\u4f7f\u7528\u65f6\u9700\u5728\u5e72\u71e5\u60f0\u6027\u6c14\u6c1b\u4e0b\u64cd\u4f5c\uff0c\u82e5\u9700\u6eb6\u89e3\uff0c\u63a8\u8350\u4f7f\u7528\u65e0\u6c34\u4e59\u9187\u6216\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u3002\u672c\u54c1\u5bf9\u7a7a\u6c14\u654f\u611f\uff0c\u5efa\u8bae\u73b0\u914d\u73b0\u7528\uff0c\u5269\u4f59\u6eb6\u6db2\u9700\u51b7\u51bb\u4fdd\u5b58\u5e76\u4e8e48\u5c0f\u65f6\u5185\u4f7f\u7528\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u54c1\u7ecfHPLC\u68c0\u6d4b\u7eaf\u5ea6>96%\uff0c\u6b8b\u7559\u6eb6\u5242\u7b26\u5408ICH\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\u8868\u660e\uff0c\u5176\u6025\u6027\u6bd2\u6027\u8f83\u4f4e\uff08LD50>500 mg\/kg\uff0c\u5927\u9f20\u53e3\u670d\uff09\uff0c\u4f46\u4ecd\u9700\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u6216\u5438\u5165\u7c89\u5c18\u3002\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u3001\u62a4\u76ee\u955c\u53ca\u9632\u5c18\u53e3\u7f69\uff0c\u82e5\u63a5\u89e6\u773c\u775b\u5e94\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u5e76\u5c31\u533b\u3002\u5e9f\u5f03\u7269\u5904\u7406\u9700\u7b26\u5408\u5f53\u5730\u5316\u5b66\u54c1\u7ba1\u7406\u6cd5\u89c4\u3002 <\/p>\n
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