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2-(2,4-\u4e8c\u6c1f\u82ef\u57fa)-2,2-\u4e8c\u6c1f\u4e59\u70f7-1-\u9187\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n

1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u54c1\u4e3a\u542b\u6c1f\u82b3\u9999\u65cf\u5316\u5408\u7269\uff0c\u5316\u5b66\u540d\u79f0\u4e3a2-(2,4-difluorophenyl)-2,2-difluoroethan-1-ol\uff0cCAS\u53f71581274-08-9\uff0c\u5206\u5b50\u5f0fC8H6F4O\uff0c\u5206\u5b50\u91cf194.126\u3002\u5916\u89c2\u4e3a\u65e0\u8272\u81f3\u6de1\u9ec4\u8272\u900f\u660e\u6db2\u4f53\uff0c\u7eaf\u5ea6\u226596%\uff08HPLC\uff09\u3002\u5176\u7ed3\u6784\u4e2d\u7684\u4e8c\u6c1f\u82ef\u57fa\u4e0e\u4e8c\u6c1f\u4e59\u9187\u57fa\u56e2\u8d4b\u4e88\u5206\u5b50\u9ad8\u7535\u8d1f\u6027\u548c\u8102\u6eb6\u6027\uff0c25\u2103\u65f6\u5bc6\u5ea6\u7ea61.45 g\/cm\u00b3\uff0c\u9700\u907f\u5149\u4fdd\u5b58\u3002 <\/p>\n

2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u542b\u6c1f\u751f\u7269\u7535\u5b50\u7b49\u6392\u4f53\uff0c\u8be5\u5316\u5408\u7269\u53ef\u901a\u8fc7\u6c1f\u539f\u5b50\u6a21\u62df\u7f9f\u57fa\u6216\u6c22\u952e\u4f9b\u4f53\uff0c\u663e\u8457\u6539\u53d8\u6bcd\u4f53\u5206\u5b50\u7684\u4ee3\u8c22\u7a33\u5b9a\u6027\u548c\u819c\u7a7f\u900f\u6027\u3002\u5176\u7279\u6b8a\u7ed3\u6784\u5728\u836f\u7269\u8bbe\u8ba1\u4e2d\u5e38\u7528\u4e8e\uff1a
\n– \u8c03\u8282\u5c0f\u5206\u5b50\u836f\u7269\u7684pKa\u503c
\n– \u589e\u5f3a\u4e0e\u9776\u86cb\u767d\u758f\u6c34\u53e3\u888b\u7684\u7ed3\u5408\u529b
\n– \u964d\u4f4e\u6c27\u5316\u4ee3\u8c22\u901f\u7387\u4ee5\u5ef6\u957f\u534a\u8870\u671f <\/p>\n

3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n3.1 \u533b\u836f\u7814\u53d1\uff1a\u7528\u4f5c\u6297\u771f\u83cc\u836f\u548c\u6297\u80bf\u7624\u5316\u5408\u7269\u7684\u5173\u952e\u4e2d\u95f4\u4f53\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u4e09\u5511\u7c7b\u836f\u7269\u7684\u7ed3\u6784\u4fee\u9970
\n3.2 \u6750\u6599\u79d1\u5b66\uff1a\u5408\u6210\u542b\u6c1f\u6db2\u6676\u6750\u6599\u7684\u5355\u4f53\u7ec4\u5206
\n3.3 \u519c\u836f\u5316\u5b66\uff1a\u5f00\u53d1\u65b0\u578b\u542b\u6c1f\u6740\u866b\u5242\u7684\u589e\u6548\u5242
\n3.4 \u79d1\u7814\u9886\u57df\uff1a\u4f5c\u4e3a19F-NMR\u63a2\u9488\u7684\u6807\u8bb0\u524d\u4f53 <\/p>\n

4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u50a8\u5b58\u4e8e\u60f0\u6027\u6c14\u4f53\uff08\u5982\u6c29\u6c14\uff09\u4fdd\u62a4\u7684\u5bc6\u5c01\u5bb9\u5668\u4e2d\uff0c\u6e29\u5ea6-20\u2103\u81f34\u2103\uff0c\u6709\u6548\u671f24\u4e2a\u6708\u3002\u4f7f\u7528\u65f6\u9700\u5728\u5e72\u71e5\u73af\u5883\u4e0b\u64cd\u4f5c\uff0c\u5efa\u8bae\u4f69\u6234\u4e01\u8148\u624b\u5957\u548c\u62a4\u76ee\u955c\u3002\u6eb6\u89e3\u6027\u6d4b\u8bd5\u8868\u660e\u6613\u6eb6\u4e8eDMF\u3001DMSO\u7b49\u6781\u6027\u975e\u8d28\u5b50\u6eb6\u5242\uff08>50 mg\/mL\uff09\uff0c\u6c34\u6eb6\u6027<0.1 mg\/mL\u3002 \n\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f \n\u6279\u6b21\u7eaf\u5ea6\u901a\u8fc7HPLC\uff08C18\u67f1\uff0c\u4e59\u8148\/\u6c34\u68af\u5ea6\u6d17\u8131\uff09\u548cGC-MS\u53cc\u91cd\u9a8c\u8bc1\uff0c\u6b8b\u7559\u6eb6\u5242\u7b26\u5408ICH Q3C\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\uff1a\u6025\u6027\u6bd2\u6027\uff08LD50\u5927\u9f20\u53e3\u670d\uff09>500 mg\/kg\uff0c\u76ae\u80a4\u523a\u6fc0\u6027\u7c7b\u522b3\u3002\u5e9f\u5f03\u7269\u5904\u7406\u9700\u9075\u5faa\u5f53\u5730\u6cd5\u89c4\uff0c\u5efa\u8bae\u91c7\u7528\u9ad8\u6e29\u711a\u70e7\u6cd5\u3002 <\/p>\n

\uff08\u6ce8\uff1a\u672c\u8bf4\u660e\u57fa\u4e8e\u73b0\u6709\u7814\u7a76\u6570\u636e\uff0c\u5b9e\u9645\u5e94\u7528\u524d\u8bf7\u52a1\u5fc5\u67e5\u9605\u6700\u65b0\u6587\u732e\u5e76\u5f00\u5c55\u5c0f\u8bd5\u5b9e\u9a8c\uff09<\/p>\n","protected":false},"featured_media":27307,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-55637","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/1581274-08-9.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/55637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/27307"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=55637"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=55637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}