1-(4-\u6c2f-2-\u6c1f\u82ef\u57fa)\u73af\u4e19\u70f7-1-\u7532\u8148\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u5316\u5b66\u540d\u79f0\u4e3a1-(4-chloro-2-fluorophenyl)cyclopropane-1-carbonitrile\uff0cCAS\u53f7\u4e3a1260750-70-6\uff0c\u5206\u5b50\u5f0f\u4e3aC10H7ClFN\uff0c\u5206\u5b50\u91cf\u4e3a195.62\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u7eaf\u5ea6\u7ecf\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\uff08HPLC\uff09\u6d4b\u5b9a\u5927\u4e8e96%\u3002\u5176\u7ed3\u6784\u4e2d\u542b\u6c1f\u3001\u6c2f\u53d6\u4ee3\u57fa\u53ca\u73af\u4e19\u70f7\u7532\u8148\u57fa\u56e2\uff0c\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u7535\u5b50\u6548\u5e94\u548c\u7a7a\u95f4\u4f4d\u963b\u7279\u6027\uff0c\u9002\u5408\u4f5c\u4e3a\u6709\u673a\u5408\u6210\u4e2d\u95f4\u4f53\u6216\u836f\u7269\u7814\u53d1\u4e2d\u7684\u5173\u952e\u780c\u5757\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u8be5\u5316\u5408\u7269\u56e0\u5176\u82ef\u73af\u4e0a\u7684\u5364\u7d20\u53d6\u4ee3\uff08\u6c1f\u3001\u6c2f\uff09\u548c\u73af\u4e19\u70f7\u7532\u8148\u57fa\u56e2\uff0c\u8868\u73b0\u51fa\u663e\u8457\u7684\u751f\u7269\u6d3b\u6027\u6f5c\u529b\u3002\u6c1f\u539f\u5b50\u7684\u5f15\u5165\u53ef\u589e\u5f3a\u8102\u6eb6\u6027\u548c\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u800c\u73af\u4e19\u70f7\u7ed3\u6784\u80fd\u8c03\u8282\u5206\u5b50\u6784\u8c61\uff0c\u4f7f\u5176\u5728\u836f\u7269\u5316\u5b66\u4e2d\u5e38\u7528\u4e8e\u4f18\u5316\u5148\u5bfc\u5316\u5408\u7269\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u6027\u8d28\u3002\u5176\u7532\u8148\u57fa\u56e2\u53ef\u4f5c\u4e3a\u6c22\u952e\u53d7\u4f53\uff0c\u53c2\u4e0e\u9776\u6807\u86cb\u767d\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u56e0\u6b64\u5728\u6fc0\u9176\u6291\u5236\u5242\u6216G\u86cb\u767d\u5076\u8054\u53d7\u4f53\u8c03\u8282\u5242\u7684\u5f00\u53d1\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u4ea7\u54c1\u4e3b\u8981\u5e94\u7528\u4e8e\u533b\u836f\u7814\u53d1\u548c\u7cbe\u7ec6\u5316\u5de5\u9886\u57df\u3002\u5728\u836f\u7269\u5408\u6210\u4e2d\uff0c\u5b83\u662f\u6784\u5efa\u6297\u80bf\u7624\u3001\u6297\u708e\u6216\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u836f\u7269\u7684\u91cd\u8981\u4e2d\u95f4\u4f53\u3002\u4f8b\u5982\uff0c\u53ef\u7528\u4e8e\u5408\u6210\u542b\u6c1f\u6742\u73af\u7c7b\u5316\u5408\u7269\uff0c\u6216\u4f5c\u4e3aPD-1\/PD-L1\u6291\u5236\u5242\u7c7b\u836f\u7269\u7684\u524d\u4f53\u3002\u5728\u6750\u6599\u79d1\u5b66\u4e2d\uff0c\u5176\u521a\u6027\u73af\u4e19\u70f7\u7ed3\u6784\u53ef\u7528\u4e8e\u8bbe\u8ba1\u9ad8\u6027\u80fd\u6db2\u6676\u6750\u6599\u6216\u5149\u654f\u5206\u5b50\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5bc6\u5c01\u4fdd\u5b58\u4e8e-20\u00b0C\u81f34\u00b0C\u7684\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u5149\u7167\u548c\u6f6e\u6e7f\u3002\u957f\u671f\u50a8\u5b58\u9700\u5145\u5165\u60f0\u6027\u6c14\u4f53\uff08\u5982\u6c2e\u6c14\uff09\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u5e94\u5728\u901a\u98ce\u6a71\u4e2d\u64cd\u4f5c\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u6216\u5438\u5165\u7c89\u5c18\u3002\u6eb6\u89e3\u6027\u6d4b\u8bd5\u8868\u660e\uff0c\u8be5\u4ea7\u54c1\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u548c\u4e19\u916e\uff0c\u5fae\u6eb6\u4e8e\u7532\u9187\uff0c\u4e0d\u6eb6\u4e8e\u6c34\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
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