2-Methyl-2-propanyl (5-bromo-1,3-thiazol-2-yl)methylcarbamate\u4ea7\u54c1\u8bf4\u660e\u4e66<\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u5316\u5b66\u540d\u79f0\u4e3a2-Methyl-2-propanyl (5-bromo-1,3-thiazol-2-yl)methylcarbamate\uff0cCAS\u53f71314095-64-1\uff0c\u5206\u5b50\u5f0fC9H13BrN2O2S\uff0c\u5206\u5b50\u91cf293.181\u3002\u5176\u7ed3\u6784\u4e2d\u5305\u542b\u6eb4\u4ee3\u567b\u5511\u73af\u4e0e\u6c28\u57fa\u7532\u9178\u916f\u57fa\u56e2\uff0c\u7eaf\u5ea6\u7ecfHPLC\u9a8c\u8bc1\u226596%\u3002\u8be5\u5316\u5408\u7269\u5728\u5e38\u6e29\u4e0b\u7a33\u5b9a\uff0c\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u548c\u7532\u9187\uff0c\u5fae\u6eb6\u4e8e\u6c34\uff0825\u2103\u65f6\u6eb6\u89e3\u5ea6<0.1mg\/mL\uff09\u3002\n\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027 \n\u4f5c\u4e3a\u567b\u5511\u7c7b\u884d\u751f\u7269\uff0c\u8be5\u5206\u5b50\u53ef\u901a\u8fc7\u6291\u5236\u03b3-\u6c28\u57fa\u4e01\u9178\uff08GABA\uff09\u53d7\u4f53\u53d1\u6325\u795e\u7ecf\u8c03\u8282\u4f5c\u7528\u3002\u6eb4\u539f\u5b50\u7684\u5f15\u5165\u589e\u5f3a\u4e86\u5176\u8102\u6eb6\u6027\uff0c\u4f7f\u5176\u66f4\u6613\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u3002\u6c28\u57fa\u7532\u9178\u916f\u57fa\u56e2\u5219\u8d4b\u4e88\u5176\u53ef\u9006\u6027\u9176\u6291\u5236\u7279\u6027\uff0c\u5728\u795e\u7ecf\u836f\u7406\u5b66\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002\n\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014 \n\u672c\u54c1\u4e3b\u8981\u5e94\u7528\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a \n3.1 \u795e\u7ecf\u79d1\u5b66\u7814\u7a76\uff1a\u4f5c\u4e3aGABA\u53d7\u4f53\u4e9a\u578b\u7684\u9009\u62e9\u6027\u914d\u4f53\uff0c\u7528\u4e8e\u7814\u7a76\u766b\u75eb\u3001\u7126\u8651\u7b49\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6a21\u578b\u3002 \n3.2 \u519c\u836f\u5f00\u53d1\uff1a\u4f5c\u4e3a\u65b0\u578b\u6740\u866b\u5242\u524d\u4f53\u5316\u5408\u7269\uff0c\u4f5c\u7528\u4e8e\u6606\u866b\u795e\u7ecf\u7cfb\u7edf\u3002 \n3.3 \u836f\u7269\u5316\u5b66\uff1a\u7528\u4e8e\u6784\u5efa\u5177\u6709CNS\u6d3b\u6027\u7684\u5148\u5bfc\u5316\u5408\u7269\uff0c\u7279\u522b\u9002\u7528\u4e8e\u6297\u60ca\u53a5\u836f\u7269\u7814\u53d1\u3002 \n\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae \n4.1 \u50a8\u5b58\u6761\u4ef6\uff1a\u5efa\u8bae\u5bc6\u5c01\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u5149\u7167\u4e0e\u6e7f\u6c14\u3002 \n4.2 \u6eb6\u89e3\u5efa\u8bae\uff1a\u4f7f\u7528\u524d\u9700\u4ee5DMSO\u914d\u5236\u6bcd\u6db2\uff08\u63a8\u8350\u6d53\u5ea610mM\uff09\uff0c\u540e\u7eed\u7528\u7f13\u51b2\u6db2\u7a00\u91ca\u81f3\u5de5\u4f5c\u6d53\u5ea6\u3002 \n4.3 \u6ce8\u610f\u4e8b\u9879\uff1a\u6eb6\u6db2\u73b0\u914d\u73b0\u7528\uff0c\u53cd\u590d\u51bb\u878d\u4e0d\u8d85\u8fc73\u6b21\u3002 \n\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f \n5.1 \u8d28\u91cf\u63a7\u5236\uff1a\u6279\u6b21\u68c0\u6d4b\u5305\u542bHPLC\u7eaf\u5ea6\u5206\u6790\uff08\u226596%\uff09\u3001\u6c34\u5206\u542b\u91cf\uff08\u22640.5%\uff09\u53ca\u91cd\u91d1\u5c5e\u6b8b\u7559\uff08\u226410ppm\uff09\u3002 \n5.2 \u5b89\u5168\u6570\u636e\uff1a\u6839\u636eGHS\u5206\u7c7b\u4e3a\u6025\u6027\u6bd2\u6027\uff08\u7c7b\u522b4\uff09\uff0c\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u53ca\u62a4\u76ee\u955c\u3002 \n5.3 \u5e9f\u5f03\u7269\u5904\u7406\uff1a\u5e94\u4f5c\u4e3a\u5371\u9669\u5316\u5b66\u54c1\u5904\u7f6e\uff0c\u4e0d\u53ef\u76f4\u63a5\u6392\u5165\u4e0b\u6c34\u9053\u3002 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