5-(4-\u6eb4\u82ef\u57fa)-6-[2-(5-\u6eb4\u5627\u5576-2-\u57fa)\u6c27\u4e59\u6c27\u57fa]-N-(\u4e59\u57fa\u78fa\u9170\u57fa)\u5627\u5576-4-\u80fa\uff08\u9a6c\u897f\u66ff\u5766\u539f\u6599\u836f\u6742\u8d28D\uff09\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u4e3a\u9a6c\u897f\u66ff\u5766\u539f\u6599\u836f\u5408\u6210\u8fc7\u7a0b\u4e2d\u4ea7\u751f\u7684\u7279\u5b9a\u6742\u8d28\uff0c\u5316\u5b66\u540d\u79f0\u4e3a5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(ethylsulfamoyl)pyrimidin-4-amine\uff0cCAS\u53f7441796-13-0\u3002\u5176\u5206\u5b50\u5f0f\u4e3aC18H18Br2N6O4S\uff0c\u5206\u5b50\u91cf574.246\uff0c\u7eaf\u5ea6>96%\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u5177\u6709\u6eb4\u4ee3\u82b3\u9999\u73af\u548c\u5627\u5576\u73af\u7ed3\u6784\uff0c\u5c5e\u4e8e\u78fa\u9170\u80fa\u7c7b\u884d\u751f\u7269\uff0c\u5728\u6709\u673a\u6eb6\u5242\u5982DMSO\u4e2d\u6eb6\u89e3\u6027\u826f\u597d\uff0c\u6c34\u6eb6\u6027\u8f83\u4f4e\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u9a6c\u897f\u66ff\u5766\u7684\u5173\u952e\u5de5\u827a\u6742\u8d28\uff0c\u672c\u54c1\u5728\u836f\u7269\u8d28\u91cf\u63a7\u5236\u4e2d\u5177\u6709\u91cd\u8981\u53c2\u8003\u4ef7\u503c\u3002\u5176\u7ed3\u6784\u4e0e\u6bcd\u4f53\u836f\u7269\u76f8\u4f3c\uff0c\u53ef\u80fd\u5f71\u54cd\u836f\u7269\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002\u901a\u8fc7\u76d1\u6d4b\u8be5\u6742\u8d28\u7684\u542b\u91cf\uff0c\u53ef\u4f18\u5316\u5408\u6210\u5de5\u827a\u3001\u786e\u4fdd\u539f\u6599\u836f\u7b26\u5408ICH\u6307\u5bfc\u539f\u5219\uff08\u6742\u8d28\u542b\u91cf\u22640.15%\uff09\uff0c\u5e76\u4e3a\u836f\u7269\u7a33\u5b9a\u6027\u7814\u7a76\u63d0\u4f9b\u6807\u51c6\u5bf9\u7167\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u54c1\u4e3b\u8981\u7528\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a\u836f\u7269\u7814\u53d1\u4e2d\u4f5c\u4e3a\u6742\u8d28\u5bf9\u7167\u54c1\u7528\u4e8eHPLC\u6216LC-MS\u5206\u6790\uff1b\u5236\u836f\u4f01\u4e1a\u8fdb\u884c\u65b9\u6cd5\u5b66\u9a8c\u8bc1\u53ca\u5de5\u827a\u4f18\u5316\uff1b\u76d1\u7ba1\u673a\u6784\u5f00\u5c55\u836f\u54c1\u8d28\u91cf\u62bd\u67e5\u68c0\u9a8c\u3002\u5728\u5177\u4f53\u5e94\u7528\u4e2d\uff0c\u9700\u914d\u5236\u6210\u9002\u5f53\u6d53\u5ea6\u7684\u6807\u51c6\u6eb6\u6db2\uff0c\u7528\u4e8e\u5efa\u7acb\u6742\u8d28\u5b9a\u91cf\u5206\u6790\u65b9\u6cd5\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u50a8\u5b58\u4e8e2-8\u2103\u907f\u5149\u73af\u5883\u4e2d\uff0c\u957f\u671f\u4fdd\u5b58\u9700\u7f6e\u4e8e\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4e0b\u3002\u5f00\u5c01\u540e\u9700\u5bc6\u5c01\u9632\u6f6e\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u4f7f\u7528\u524d\u9700\u5e73\u8861\u81f3\u5ba4\u6e29\uff0c\u79f0\u91cf\u65f6\u4f7f\u7528\u9632\u9759\u7535\u5668\u5177\u3002\u63a8\u8350\u5de5\u4f5c\u6d53\u5ea6\u4e3a0.1-1.0 mg\/mL\uff08\u6eb6\u5242\u4e3a\u4e59\u8148\u6216\u7532\u9187\uff09\uff0c\u6eb6\u6db2\u73b0\u914d\u73b0\u7528\uff0c24\u5c0f\u65f6\u5185\u672a\u7528\u5b8c\u5e94\u5e9f\u5f03\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u7ecfHPLC\u3001NMR\u548c\u8d28\u8c31\u4e09\u91cd\u9a8c\u8bc1\uff0c\u7b26\u5408EP\/USP\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\uff1aGHS\u5206\u7c7b\u4e3a\u6025\u6027\u6bd2\u6027\uff08\u53e3\u670d\/\u5438\u5165\u7c7b\u522b4\uff09\u3001\u76ae\u80a4\u523a\u6fc0\u6027\uff08\u7c7b\u522b2\uff09\uff0c\u64cd\u4f5c\u65f6\u5e94\u7a7f\u6234\u9632\u62a4\u624b\u5957\u3001\u62a4\u76ee\u955c\u53ca\u9632\u5c18\u53e3\u7f69\u3002\u5982\u63a5\u89e6\u76ae\u80a4\uff0c\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\uff1b\u82e5\u5438\u5165\uff0c\u8f6c\u79fb\u81f3\u7a7a\u6c14\u65b0\u9c9c\u5904\u3002\u5e9f\u5f03\u7269\u5904\u7f6e\u9700\u7b26\u5408\u5f53\u5730\u5371\u9669\u5316\u5b66\u54c1\u7ba1\u7406\u6cd5\u89c4\u3002 <\/p>\n
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