1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\ndBET1\uff08\u5316\u5b66\u540d\u79f0\uff1adBET1\uff0cCAS\u53f7\uff1a1799711-21-9\uff09\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5206\u5b50\u5f0f\u4e3aC38H37ClN8O7S\uff0c\u5206\u5b50\u91cf\u4e3a785.268\u3002\u8be5\u5316\u5408\u7269\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5177\u6709\u660e\u786e\u7684\u5316\u5b66\u7ed3\u6784\u548c\u7a33\u5b9a\u7684\u7406\u5316\u6027\u8d28\u3002dBET1\u5c5e\u4e8e\u86cb\u767d\u964d\u89e3\u9776\u5411\u5d4c\u5408\u4f53\uff08PROTAC\uff09\u7c7b\u5316\u5408\u7269\uff0c\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408\u9776\u86cb\u767d\u548cE3\u6cdb\u7d20\u8fde\u63a5\u9176\uff0c\u8bf1\u5bfc\u9776\u86cb\u767d\u7684\u6cdb\u7d20\u5316\u548c\u964d\u89e3\u3002\u5176\u7ed3\u6784\u4e2d\u5305\u542b\u6c2f\u539f\u5b50\u548c\u78fa\u9170\u57fa\u7b49\u6d3b\u6027\u57fa\u56e2\uff0c\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u751f\u7269\u6d3b\u6027\u548c\u9009\u62e9\u6027\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\ndBET1\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u53cc\u529f\u80fd\u964d\u89e3\u5242\uff0c\u4e3b\u8981\u9776\u5411BRD4\u86cb\u767d\u3002\u5b83\u901a\u8fc7\u540c\u65f6\u7ed3\u5408BRD4\u548cE3\u6cdb\u7d20\u8fde\u63a5\u9176CRBN\uff0c\u5f62\u6210\u4e09\u5143\u590d\u5408\u7269\uff0c\u4ece\u800c\u89e6\u53d1BRD4\u7684\u6cdb\u7d20\u5316\u5e76\u4fc3\u8fdb\u5176\u901a\u8fc7\u86cb\u767d\u9176\u4f53\u9014\u5f84\u964d\u89e3\u3002\u8fd9\u4e00\u673a\u5236\u5728\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u548c\u80bf\u7624\u6cbb\u7597\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u5c24\u5176\u5728\u8840\u6db2\u7cfb\u7edf\u6076\u6027\u80bf\u7624\u548c\u5b9e\u4f53\u7624\u7684\u6cbb\u7597\u4e2d\u5c55\u73b0\u51fa\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002dBET1\u7684\u53d1\u73b0\u4e3a\u9776\u5411\u86cb\u767d\u964d\u89e3\u6280\u672f\u63d0\u4f9b\u4e86\u91cd\u8981\u5de5\u5177\uff0c\u63a8\u52a8\u4e86\u76f8\u5173\u9886\u57df\u7684\u7814\u7a76\u8fdb\u5c55\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\ndBET1\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5206\u5b50\u751f\u7269\u5b66\u548c\u836f\u7269\u7814\u53d1\u9886\u57df\uff0c\u5177\u4f53\u7528\u9014\u5305\u62ec\uff1a
\n\uff081\uff09\u7814\u7a76BRD4\u86cb\u767d\u7684\u529f\u80fd\u53ca\u5176\u5728\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1b
\n\uff082\uff09\u63a2\u7d22PROTAC\u6280\u672f\u5728\u9776\u5411\u86cb\u767d\u964d\u89e3\u4e2d\u7684\u5e94\u7528\uff1b
\n\uff083\uff09\u4f5c\u4e3a\u5de5\u5177\u5316\u5408\u7269\u7528\u4e8e\u7b5b\u9009\u548c\u5f00\u53d1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\uff1b
\n\uff084\uff09\u7528\u4e8e\u8868\u89c2\u9057\u4f20\u5b66\u7814\u7a76\u548c\u4fe1\u53f7\u901a\u8def\u5206\u6790\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\ndBET1\u5e94\u50a8\u5b58\u4e8e-20\u00b0C\u4ee5\u4e0b\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u4f7f\u7528\u65f6\u5efa\u8bae\u5c06\u7c89\u672b\u6eb6\u89e3\u4e8eDMSO\u6216\u5176\u4ed6\u9002\u5f53\u6eb6\u5242\u4e2d\uff0c\u914d\u5236\u6210\u6bcd\u6db2\u540e\u5206\u88c5\u4fdd\u5b58\u3002\u5de5\u4f5c\u6d53\u5ea6\u9700\u6839\u636e\u5b9e\u9a8c\u4f53\u7cfb\u4f18\u5316\uff0c\u63a8\u8350\u8d77\u59cb\u6d53\u5ea6\u4e3a10-100 nM\u3002\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u548c\u62a4\u76ee\u955c\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u6216\u5438\u5165\u7c89\u5c18\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u901a\u8fc7HPLC\u548c\u8d28\u8c31\u5206\u6790\u786e\u4fdd\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5e76\u63d0\u4f9b\u5b8c\u6574\u7684\u8d28\u68c0\u62a5\u544a\u3002dBET1\u5177\u6709\u4e00\u5b9a\u6bd2\u6027\uff0c\u9700\u5728\u751f\u7269\u5b89\u5168\u67dc\u4e2d\u64cd\u4f5c\uff0c\u5e9f\u5f03\u7269\u5e94\u6309\u7167\u5371\u9669\u5316\u5b66\u54c1\u5904\u7406\u89c4\u8303\u5904\u7f6e\u3002\u5b9e\u9a8c\u52a8\u7269\u7814\u7a76\u9700\u9075\u5faa\u4f26\u7406\u51c6\u5219\u3002\u5982\u4e0d\u614e\u63a5\u89e6\uff0c\u5e94\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u5e76\u5c31\u533b\u3002 <\/p>\n
\u4ee5\u4e0a\u4fe1\u606f\u4ec5\u4f9b\u53c2\u8003\uff0c\u5177\u4f53\u5b9e\u9a8c\u65b9\u6848\u9700\u6839\u636e\u5b9e\u9645\u9700\u6c42\u8c03\u6574\u3002\u5efa\u8bae\u4f7f\u7528\u8005\u67e5\u9605\u76f8\u5173\u6587\u732e\u5e76\u54a8\u8be2\u4e13\u4e1a\u4eba\u58eb\u4ee5\u786e\u4fdd\u5b9e\u9a8c\u5b89\u5168\u548c\u6709\u6548\u6027\u3002<\/p>\n","protected":false},"featured_media":28030,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-54708","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/1799711-21-9.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/54708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/28030"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=54708"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=54708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}