1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n(3\u03b2,24R)-24,25-Epoxycholest-5-en-3-ol\uff08CAS\u53f7\uff1a72542-49-5\uff09\u662f\u4e00\u79cd\u753e\u9187\u7c7b\u5316\u5408\u7269\uff0c\u5206\u5b50\u5f0f\u4e3aC27H44O2\uff0c\u5206\u5b50\u91cf\u4e3a400.637\u3002\u8be5\u5316\u5408\u7269\u5c5e\u4e8e\u80c6\u56fa\u9187\u884d\u751f\u7269\uff0c\u7ed3\u6784\u4e2d\u5305\u542b\u4e00\u4e2a\u73af\u6c27\u57fa\u56e2\uff0824,25-\u73af\u6c27\uff09\u548c\u4e00\u4e2a\u7f9f\u57fa\uff083\u03b2-\u7f9f\u57fa\uff09\uff0c\u5176\u5316\u5b66\u7eaf\u5ea6\u8d85\u8fc796%\u3002\u8be5\u7269\u8d28\u901a\u5e38\u4ee5\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6216\u7c89\u672b\u5f62\u5f0f\u5b58\u5728\uff0c\u5177\u6709\u5178\u578b\u7684\u753e\u9187\u7c7b\u758f\u6c34\u6027\u7279\u5f81\uff0c\u53ef\u6eb6\u4e8e\u6709\u673a\u6eb6\u5242\u5982\u6c2f\u4eff\u3001\u7532\u9187\u548c\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\uff0c\u4f46\u5728\u6c34\u4e2d\u6eb6\u89e3\u5ea6\u8f83\u4f4e\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u80c6\u56fa\u9187\u4ee3\u8c22\u9014\u5f84\u4e2d\u7684\u5173\u952e\u4e2d\u95f4\u4f53\uff0c(3\u03b2,24R)-24,25-Epoxycholest-5-en-3-ol\u5728\u753e\u9187\u751f\u7269\u5408\u6210\u548c\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u53d1\u6325\u91cd\u8981\u4f5c\u7528\u3002\u5b83\u53c2\u4e0e\u8c03\u63a7\u7ec6\u80de\u819c\u6d41\u52a8\u6027\u3001\u80c6\u6c41\u9178\u5408\u6210\u4ee5\u53ca\u7ef4\u751f\u7d20D\u524d\u4f53\u7684\u751f\u6210\u3002\u6b64\u5916\uff0c\u5176\u73af\u6c27\u7ed3\u6784\u5728\u6c27\u5316\u5e94\u6fc0\u548c\u7ec6\u80de\u51cb\u4ea1\u7814\u7a76\u4e2d\u5177\u6709\u7279\u6b8a\u610f\u4e49\uff0c\u662f\u7814\u7a76\u8102\u8d28\u4ee3\u8c22\u5f02\u5e38\u76f8\u5173\u75be\u75c5\uff08\u5982\u52a8\u8109\u7ca5\u6837\u786c\u5316\uff09\u7684\u91cd\u8981\u5de5\u5177\u5206\u5b50\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u8be5\u5316\u5408\u7269\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7814\u7a76\u548c\u5236\u836f\u5f00\u53d1\u9886\u57df\u3002\u5728\u57fa\u7840\u7814\u7a76\u4e2d\uff0c\u5b83\u88ab\u7528\u4f5c\u6807\u51c6\u54c1\u6216\u5e95\u7269\uff0c\u7528\u4e8e\u5206\u6790\u80c6\u56fa\u9187\u4ee3\u8c22\u9176\uff08\u5982CYP450\u5bb6\u65cf\u9176\uff09\u7684\u6d3b\u6027\u3002\u5728\u836f\u7269\u7814\u53d1\u4e2d\uff0c\u53ef\u7528\u4e8e\u7b5b\u9009\u8c03\u8282\u80c6\u56fa\u9187\u5408\u6210\u7684\u5019\u9009\u5316\u5408\u7269\u3002\u6b64\u5916\uff0c\u5728\u7ec6\u80de\u751f\u7269\u5b66\u5b9e\u9a8c\u4e2d\uff0c\u5b83\u5e38\u7528\u4e8e\u63a2\u7a76\u753e\u9187\u5bf9\u819c\u53d7\u4f53\uff08\u5982Smoothened\u86cb\u767d\uff09\u7684\u8c03\u63a7\u673a\u5236\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
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5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
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