1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u963f\u5947\u6c99\u5766\u80c6\u78b1\u76d0\uff08azilsartan choline salt\uff09\u662f\u4e00\u79cd\u9ad8\u7eaf\u5ea6\u7684\u6709\u673a\u5316\u5408\u7269\uff0c\u5316\u5b66\u540d\u79f0\u4e3a\u963f\u5947\u6c99\u5766\u9178\u548c\u80c6\u78b1\u4ee52:1\u6bd4\u4f8b\u5f62\u6210\u7684\u76d0\u7c7b\u3002\u5176CAS\u53f7\u4e3a1309776-70-2\uff0c\u5206\u5b50\u5f0f\u4e3aC30H33N5O6\uff0c\u5206\u5b50\u91cf\u4e3a559.613\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u7eaf\u5ea6\u8d85\u8fc796%\uff0c\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\u548c\u7a33\u5b9a\u6027\u3002\u963f\u5947\u6c99\u5766\u80c6\u78b1\u76d0\u662f\u8840\u7ba1\u7d27\u5f20\u7d20II\u53d7\u4f53\u62ee\u6297\u5242\uff08ARB\uff09\u7c7b\u836f\u7269\u7684\u91cd\u8981\u4e2d\u95f4\u4f53\uff0c\u5176\u72ec\u7279\u7684\u76d0\u5f62\u5f0f\u53ef\u4f18\u5316\u836f\u7269\u7684\u751f\u7269\u5229\u7528\u5ea6\u548c\u7406\u5316\u6027\u8d28\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u963f\u5947\u6c99\u5766\u80c6\u78b1\u76d0\u901a\u8fc7\u9009\u62e9\u6027\u963b\u65ad\u8840\u7ba1\u7d27\u5f20\u7d20II\u4e0eAT1\u53d7\u4f53\u7684\u7ed3\u5408\uff0c\u6709\u6548\u6291\u5236\u8840\u7ba1\u6536\u7f29\u548c\u919b\u56fa\u916e\u91ca\u653e\uff0c\u4ece\u800c\u53d1\u6325\u964d\u538b\u4f5c\u7528\u3002\u4e0e\u666e\u901a\u963f\u5947\u6c99\u5766\u76f8\u6bd4\uff0c\u5176\u80c6\u78b1\u76d0\u5f62\u5f0f\u663e\u8457\u63d0\u9ad8\u4e86\u6c34\u6eb6\u6027\u548c\u53e3\u670d\u5438\u6536\u7387\uff0c\u964d\u4f4e\u4e86\u80c3\u80a0\u9053\u523a\u6fc0\u6027\uff0c\u5728\u836f\u7269\u5236\u5242\u4e2d\u8868\u73b0\u51fa\u66f4\u4f18\u8d8a\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u7279\u6027\u3002\u8fd9\u4e00\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u9ad8\u8840\u538b\u6cbb\u7597\u836f\u7269\u5f00\u53d1\u4e2d\u7684\u5173\u952e\u539f\u6599\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u4ea7\u54c1\u4e3b\u8981\u7528\u4e8e\u533b\u836f\u7814\u53d1\u9886\u57df\uff0c\u5177\u4f53\u5305\u62ec\uff1a\u4f5c\u4e3a\u539f\u6599\u836f\u4e2d\u95f4\u4f53\u7528\u4e8e\u5408\u6210\u6297\u9ad8\u8840\u538b\u836f\u7269\uff1b\u5728\u5236\u5242\u7814\u7a76\u4e2d\u7528\u4e8e\u6539\u5584\u836f\u7269\u6eb6\u89e3\u6027\u548c\u7a33\u5b9a\u6027\uff1b\u5728\u836f\u6548\u5b66\u5b9e\u9a8c\u4e2d\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\u54c1\u3002\u5176\u5178\u578b\u5e94\u7528\u573a\u666f\u6db5\u76d6\u521b\u65b0\u836f\u5f00\u53d1\u3001\u4eff\u5236\u836f\u4e00\u81f4\u6027\u8bc4\u4ef7\u53ca\u7f13\u63a7\u91ca\u5236\u5242\u6280\u672f\u7814\u7a76\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5728-20\u2103\u4e0b\u907f\u5149\u5bc6\u5c01\u4fdd\u5b58\uff0c\u957f\u671f\u50a8\u5b58\u9700\u5145\u6c2e\u4fdd\u62a4\u3002\u4f7f\u7528\u524d\u9700\u5e73\u8861\u81f3\u5ba4\u6e29\u5e76\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u6eb6\u89e3\u65f6\u5e94\u9009\u7528pH\u4e2d\u6027\u7684\u7f13\u51b2\u6eb6\u6db2\uff0c\u7981\u6b62\u4e0e\u5f3a\u6c27\u5316\u5242\u3001\u5f3a\u9178\u5f3a\u78b1\u5171\u540c\u5904\u7406\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\uff0c\u5efa\u8bae\u4f69\u6234\u9632\u62a4\u624b\u5957\u548c\u62a4\u76ee\u955c\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u901a\u8fc7HPLC\u3001NMR\u548c\u8d28\u8c31\u8fdb\u884c\u4e25\u683c\u8d28\u91cf\u63a7\u5236\uff0c\u7b26\u5408USP\/EP\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\u8868\u660e\uff0c\u5176\u6025\u6027\u6bd2\u6027\u8f83\u4f4e\uff08LD50>2000 mg\/kg\uff09\uff0c\u4f46\u4ecd\u53ef\u80fd\u5f15\u8d77\u773c\u775b\u548c\u76ae\u80a4\u523a\u6fc0\u3002\u610f\u5916\u63a5\u89e6\u65f6\u9700\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\uff0c\u5fc5\u8981\u65f6\u5c31\u533b\u3002\u5e9f\u5f03\u7269\u5e94\u4f5c\u4e3a\u5371\u9669\u5316\u5b66\u54c1\u5904\u7406\uff0c\u9075\u5b88\u5f53\u5730\u73af\u4fdd\u6cd5\u89c4\u3002 <\/p>\n
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