3-(2′-\u4e19\u6c27\u57fa)-5-\u6c28\u57fa\u4e09\u6c1f\u7532\u82ef\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u54c1\u5316\u5b66\u540d\u79f0\u4e3a3-(2′-propyloxy)-5-aminobenzotrifluoride\uff08CAS 1280201-29-7\uff09\uff0c\u4e2d\u6587\u522b\u540d3-\u5f02\u4e19\u6c27\u57fa-5-\u4e09\u6c1f\u7532\u57fa\u82ef\u80fa\uff0c\u5206\u5b50\u5f0fC10H12F3NO\uff0c\u5206\u5b50\u91cf219.204\u3002\u4e3a\u6de1\u9ec4\u8272\u81f3\u65e0\u8272\u7ed3\u6676\u6216\u7c89\u672b\u72b6\u56fa\u4f53\uff0c\u7eaf\u5ea6\u226596%\u3002\u5176\u7ed3\u6784\u4e2d\u7684\u4e09\u6c1f\u7532\u57fa\u548c\u6c28\u57fa\u8d4b\u4e88\u5206\u5b50\u5f3a\u6781\u6027\u53ca\u7535\u5b50\u6548\u5e94\uff0c\u5f02\u4e19\u6c27\u57fa\u5219\u589e\u5f3a\u8102\u6eb6\u6027\uff0c\u4f7f\u5176\u5728\u6709\u673a\u6eb6\u5242\u4e2d\u5177\u6709\u826f\u597d\u7684\u6eb6\u89e3\u6027\uff08\u5982\u7532\u9187\u3001\u4e59\u9187\u3001\u4e8c\u6c2f\u7532\u70f7\uff09\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u542b\u6c1f\u82b3\u9999\u80fa\u884d\u751f\u7269\uff0c\u8be5\u5316\u5408\u7269\u662f\u5408\u6210\u533b\u836f\u3001\u519c\u836f\u53ca\u6750\u6599\u79d1\u5b66\u5173\u952e\u4e2d\u95f4\u4f53\u7684\u6838\u5fc3\u9aa8\u67b6\u3002\u4e09\u6c1f\u7532\u57fa\u7684\u5f3a\u5438\u7535\u5b50\u7279\u6027\u53ef\u663e\u8457\u8c03\u8282\u5206\u5b50\u4eb2\u8102\u6027\u4e0e\u4ee3\u8c22\u7a33\u5b9a\u6027\uff0c\u6c28\u57fa\u5219\u63d0\u4f9b\u6d3b\u6027\u4f4d\u70b9\u7528\u4e8e\u540e\u7eed\u7f29\u5408\u3001\u5076\u8054\u7b49\u53cd\u5e94\u3002\u5728\u836f\u7269\u5316\u5b66\u4e2d\u5e38\u7528\u4e8e\u6784\u5efa\u6fc0\u9176\u6291\u5236\u5242\u548c\u6297\u708e\u836f\u7269\u7684\u82ef\u80fa\u7247\u6bb5\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u533b\u836f\u9886\u57df\uff1a\u7528\u4e8e\u5408\u6210\u6297\u80bf\u7624\u3001\u6297\u75c5\u6bd2\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7269\uff0c\u5c24\u5176\u662f\u542b\u4e09\u6c1f\u7532\u57fa\u7684EGFR\u6291\u5236\u5242\u3002
\n\u519c\u836f\u9886\u57df\uff1a\u4f5c\u4e3a\u9664\u8349\u5242\u548c\u6740\u83cc\u5242\u7684\u4e2d\u95f4\u4f53\uff0c\u53ef\u589e\u5f3a\u4f5c\u7269\u4fdd\u62a4\u5242\u7684\u6e17\u900f\u6027\u4e0e\u6301\u4e45\u6027\u3002
\n\u6750\u6599\u79d1\u5b66\uff1a\u53c2\u4e0e\u5236\u5907\u542b\u6c1f\u6db2\u6676\u5355\u4f53\uff0c\u6539\u5584\u663e\u793a\u6750\u6599\u7684\u4ecb\u7535\u5404\u5411\u5f02\u6027\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u50a8\u5b58\u4e8e\u5bc6\u95ed\u5bb9\u5668\u4e2d\uff0c\u907f\u5149\u3001\u9632\u6f6e\uff0c\u5efa\u8bae\u6e29\u5ea6-20\u00b0C\u81f34\u00b0C\u957f\u671f\u4fdd\u5b58\u3002\u4f7f\u7528\u524d\u9700\u6062\u590d\u81f3\u5ba4\u6e29\u5e76\u5e72\u71e5\u5904\u7406\u3002\u6eb6\u89e3\u65f6\u4f18\u5148\u9009\u7528\u60f0\u6027\u6709\u673a\u6eb6\u5242\uff0c\u907f\u514d\u4e0e\u5f3a\u6c27\u5316\u5242\u3001\u9178\u9150\u7c7b\u7269\u8d28\u63a5\u89e6\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\uff0c\u4f69\u6234\u9632\u5316\u624b\u5957\u53ca\u62a4\u76ee\u955c\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u901a\u8fc7HPLC\u68c0\u6d4b\u7eaf\u5ea6\uff0c\u6279\u6b21\u95f4\u504f\u5dee\u22641%\u3002\u6b8b\u7559\u6eb6\u5242\u7b26\u5408ICH Q3C\u6807\u51c6\u3002
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