\u53cc\u6c22\u9752\u84bf\u7d20\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u53cc\u6c22\u9752\u84bf\u7d20\uff08Dihydroartemisinin\uff0cCAS\u53f781496-81-3\uff09\u662f\u4e00\u79cd\u91cd\u8981\u7684\u500d\u534a\u841c\u5185\u916f\u884d\u751f\u7269\uff0c\u5316\u5b66\u540d\u4e3a3,6,9-\u4e09\u7532\u57fa\u5341\u6c22-12H-3,12-\u73af\u6c27[1,2]\u4e8c\u6c27\u6742\u73af\u5e9a\u5e76[4,3-i]\u5f02\u8272\u70ef-10-\u9187\u3002\u5176\u5206\u5b50\u5f0f\u4e3aC15H24O5\uff0c\u5206\u5b50\u91cf284.348\uff0c\u7eaf\u5ea6\u226596%\u3002\u672c\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u662f\u9752\u84bf\u7d20\u7684\u5173\u952e\u6d3b\u6027\u4ee3\u8c22\u4ea7\u7269\uff0c\u5177\u6709\u66f4\u7a33\u5b9a\u7684\u5316\u5b66\u7ed3\u6784\u548c\u66f4\u5f3a\u7684\u751f\u7269\u6d3b\u6027\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u53cc\u6c22\u9752\u84bf\u7d20\u901a\u8fc7\u5176\u5185\u8fc7\u6c27\u5316\u7269\u6865\u7ed3\u6784\uff08-O-O-\uff09\u53d1\u6325\u836f\u7406\u4f5c\u7528\uff0c\u5728\u94c1\u79bb\u5b50\u4ecb\u5bfc\u4e0b\u4ea7\u751f\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\uff0c\u5bf9\u759f\u539f\u866b\u7684\u819c\u7cfb\u7edf\u53ca\u86cb\u767d\u8d28\u9020\u6210\u4e0d\u53ef\u9006\u635f\u4f24\u3002\u4f5c\u4e3a\u9752\u84bf\u7d20\u7c7b\u836f\u7269\u7684\u6838\u5fc3\u4e2d\u95f4\u4f53\uff0c\u5176\u6297\u759f\u6d3b\u6027\u663e\u8457\u9ad8\u4e8e\u9752\u84bf\u7d20\uff0c\u4e14\u5bf9\u8010\u836f\u6027\u759f\u539f\u866b\u4ecd\u4fdd\u6301\u9ad8\u6548\u3002\u6b64\u5916\uff0c\u8fd1\u5e74\u7814\u7a76\u53d1\u73b0\u5176\u5728\u6297\u80bf\u7624\u3001\u514d\u75ab\u8c03\u8282\u7b49\u9886\u57df\u5177\u6709\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u54c1\u4e3b\u8981\u7528\u4e8e\u6297\u759f\u75be\u836f\u7269\uff08\u5982\u53cc\u6c22\u9752\u84bf\u7d20\u54cc\u55b9\u7247\uff09\u7684\u5408\u6210\u539f\u6599\uff0c\u4ea6\u7528\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a
\n– \u6297\u759f\u7814\u7a76\uff1a\u4f5c\u4e3a\u6807\u51c6\u54c1\u7528\u4e8e\u836f\u6548\u5b66\u53ca\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76
\n– \u836f\u7269\u5f00\u53d1\uff1a\u4fee\u9970\u5236\u5907\u9752\u84bf\u7425\u916f\u3001\u84bf\u7532\u919a\u7b49\u884d\u751f\u7269
\n– \u673a\u5236\u7814\u7a76\uff1a\u63a2\u7d22\u6d3b\u6027\u6c27\u81ea\u7531\u57fa\u5bf9\u75c5\u539f\u4f53\u7684\u4f5c\u7528\u673a\u5236
\n– \u4f53\u5916\u5b9e\u9a8c\uff1a\u7528\u4e8e\u6297\u80bf\u7624\u3001\u6297\u708e\u7b49\u7ec6\u80de\u6a21\u578b\u7814\u7a76 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u50a8\u5b58\u4e8e\u5bc6\u5c01\u907f\u5149\u5bb9\u5668\u4e2d\uff0c\u7f6e\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e0b\uff0c\u957f\u671f\u4fdd\u5b58\u5efa\u8bae\u5145\u6c2e\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u9700\u907f\u514d\u53cd\u590d\u51bb\u878d\uff0c\u6eb6\u89e3\u5efa\u8bae\u91c7\u7528\u65e0\u6c34\u4e59\u9187\u6216DMSO\uff08\u6d53\u5ea6\u226410 mM\uff09\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4e0b\u8fdb\u884c\uff0c\u4ee5\u9632\u6c27\u5316\u964d\u89e3\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u54c1\u7ecfHPLC\u68c0\u6d4b\u7eaf\u5ea6\u226596%\uff0c\u6b8b\u7559\u6eb6\u5242\u7b26\u5408ICH\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\uff1a\u6025\u6027\u6bd2\u6027\uff08\u5927\u9f20\u53e3\u670dLD50\uff09>2000 mg\/kg\uff0c\u4f46\u53ef\u80fd\u5f15\u8d77\u773c\u775b\u53ca\u76ae\u80a4\u523a\u6fc0\u3002\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u53ca\u62a4\u76ee\u955c\uff0c\u82e5\u63a5\u89e6\u76ae\u80a4\u5e94\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u3002\u5e9f\u5f03\u7269\u5904\u7f6e\u9700\u7b26\u5408\u5371\u9669\u5316\u5b66\u54c1\u7ba1\u7406\u89c4\u8303\u3002 <\/p>\n
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