4-\u6c28\u57fa\u5627\u5576\u5e76[4,5-d]\u5627\u5576\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u5316\u5b66\u540d\u79f0\u4e3apyrimido[4,5-d]pyrimidin-4-amine\uff08CAS\u53f726979-05-5\uff09\uff0c\u662f\u4e00\u79cd\u6742\u73af\u6709\u673a\u5316\u5408\u7269\uff0c\u5206\u5b50\u5f0f\u4e3aC6H5N5\uff0c\u5206\u5b50\u91cf147.137\u3002\u5176\u7ed3\u6784\u7531\u7a20\u5408\u5627\u5576\u73af\u6784\u6210\uff0c\u542b\u6709\u4e00\u4e2a\u6d3b\u6027\u6c28\u57fa\u57fa\u56e2\uff0c\u7eaf\u5ea6>96%\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u7c89\u672b\uff0c\u53ef\u6eb6\u4e8e\u6781\u6027\u6709\u673a\u6eb6\u5242\uff08\u5982DMSO\u3001\u7532\u9187\uff09\uff0c\u5fae\u6eb6\u4e8e\u6c34\uff0c\u5177\u6709\u5178\u578b\u7684\u82b3\u9999\u6742\u73af\u5316\u5b66\u6027\u8d28\uff0c\u6613\u4e8e\u53c2\u4e0e\u4eb2\u6838\u53d6\u4ee3\u548c\u7f29\u5408\u53cd\u5e94\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u5627\u5576\u7c7b\u884d\u751f\u7269\uff0c\u8be5\u5206\u5b50\u662f\u6838\u9178\u78b1\u57fa\u7684\u7ed3\u6784\u7c7b\u4f3c\u7269\uff0c\u53ef\u901a\u8fc7\u7ade\u4e89\u6027\u6291\u5236\u5e72\u6270DNA\/RNA\u5408\u6210\u9014\u5f84\u3002\u5176\u72ec\u7279\u7684\u53cc\u5627\u5576\u7a20\u73af\u7ed3\u6784\u4f7f\u5176\u80fd\u591f\u4e0e\u591a\u79cd\u9176\uff08\u5982\u6fc0\u9176\u3001\u7532\u57fa\u8f6c\u79fb\u9176\uff09\u7684\u6d3b\u6027\u4f4d\u70b9\u7ed3\u5408\uff0c\u5728\u751f\u7269\u5316\u5b66\u7814\u7a76\u4e2d\u5e38\u4f5c\u4e3a\u5c0f\u5206\u5b50\u6291\u5236\u5242\u6216\u63a2\u9488\uff0c\u7528\u4e8e\u63a2\u7d22\u6838\u82f7\u9178\u4ee3\u8c22\u3001\u4fe1\u53f7\u8f6c\u5bfc\u7b49\u5173\u952e\u751f\u7269\u5b66\u8fc7\u7a0b\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
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4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5bc6\u5c01\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u5149\u7167\u4e0e\u6f6e\u6e7f\u3002\u5f00\u5c01\u540e\u9700\u5145\u5165\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u5206\u88c5\u3002\u4f7f\u7528\u65f6\u5e94\u4f69\u6234\u9632\u62a4\u624b\u5957\u53ca\u62a4\u76ee\u955c\uff0c\u5728\u901a\u98ce\u6a71\u4e2d\u64cd\u4f5c\u3002\u6eb6\u89e3\u65f6\u4f18\u5148\u9009\u7528DMSO\uff08\u6d53\u5ea6\u5efa\u8bae\u226410mM\uff09\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5de5\u4f5c\u6db2\u9700\u73b0\u914d\u73b0\u7528\uff0c\u5269\u4f59\u6eb6\u6db2\u5efa\u8bae-80\u2103\u77ed\u671f\u4fdd\u5b58\uff08\u22641\u5468\uff09\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
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