1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u54c1\u4e3a\u6c99\u82ac\u9170\u80fa\uff08Safinamide\uff09\uff0c\u5316\u5b66\u540d\u79f0\u4e3a(2S)-2-[[4-[(3-fluorophenyl)methoxy]phenyl]methylamino]propanamide\uff0cCAS\u53f7\u4e3a133865-89-1\uff0c\u5206\u5b50\u5f0f\u4e3aC17H19FN2O2\uff0c\u5206\u5b50\u91cf\u4e3a302.343\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u5355\u80fa\u6c27\u5316\u9176B\uff08MAO-B\uff09\u6291\u5236\u6d3b\u6027\u3002\u5176\u7ed3\u6784\u4e2d\u542b\u6c1f\u82ef\u7532\u6c27\u57fa\u56e2\u548c\u624b\u6027\u4e2d\u5fc3\uff0c\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u836f\u7406\u7279\u6027\u4e0e\u4ee3\u8c22\u7a33\u5b9a\u6027\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u6c99\u82ac\u9170\u80fa\u662f\u4e00\u79cd\u53ef\u9006\u6027MAO-B\u6291\u5236\u5242\uff0c\u901a\u8fc7\u51cf\u5c11\u591a\u5df4\u80fa\u964d\u89e3\u5ef6\u957f\u5176\u795e\u7ecf\u9012\u8d28\u4f5c\u7528\uff0c\u540c\u65f6\u8c03\u8282\u8c37\u6c28\u9178\u91ca\u653e\u3002\u5176\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff08\u591a\u5df4\u80fa\u80fd\u4e0e\u975e\u591a\u5df4\u80fa\u80fd\uff09\u5728\u5e15\u91d1\u68ee\u75c5\u6cbb\u7597\u4e2d\u5c24\u4e3a\u91cd\u8981\uff0c\u53ef\u6539\u5584\u8fd0\u52a8\u75c7\u72b6\u5e76\u5ef6\u7f13\u75be\u75c5\u8fdb\u5c55\u3002\u76f8\u8f83\u4e8e\u4f20\u7edfMAO\u6291\u5236\u5242\uff0c\u5176\u9009\u62e9\u6027\u66f4\u9ad8\uff0c\u663e\u8457\u964d\u4f4e\u916a\u80fa\u53cd\u5e94\u98ce\u9669\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u4f5c\u4e3a\u6297\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u6d3b\u6027\u6210\u5206\uff0c\u6c99\u82ac\u9170\u80fa\u4e3b\u8981\u7528\u4e8e\uff1a
\n– \u65e9\u671f\u6216\u4e2d\u665a\u671f\u5e15\u91d1\u68ee\u75c5\u7684\u5355\u836f\u6216\u8054\u5408\u6cbb\u7597\uff08\u5982\u4e0e\u5de6\u65cb\u591a\u5df4\u8054\u7528\uff09
\n– \u51cf\u5c11\u8fd0\u52a8\u6ce2\u52a8\uff08\u5982”\u5242\u672b\u73b0\u8c61”\uff09\u548c\u5f02\u52a8\u75c7
\n– \u795e\u7ecf\u4fdd\u62a4\u6f5c\u529b\u7814\u7a76\uff08\u6291\u5236\u6c27\u5316\u5e94\u6fc0\u4e0e\u5174\u594b\u6bd2\u6027\uff09 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u50a8\u5b58\u4e8e\u5bc6\u95ed\u5bb9\u5668\u4e2d\uff0c\u907f\u5149\u3001\u9632\u6f6e\uff0c\u6e29\u5ea6\u63a7\u5236\u57282-8\u2103\uff08\u957f\u671f\uff09\u621625\u2103\u4ee5\u4e0b\uff08\u77ed\u671f\uff09\u3002\u6eb6\u89e3\u5efa\u8bae\u4f7f\u7528DMSO\u6216\u4e59\u9187\uff08\u6d53\u5ea6<10 mM\uff09\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\uff0c\u4f69\u6234\u9632\u62a4\u624b\u5957\u4e0e\u62a4\u76ee\u955c\u3002 \n\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f \n\u672c\u54c1\u7ecfHPLC\u68c0\u6d4b\u7eaf\u5ea6\u226596%\uff0c\u6b8b\u7559\u6eb6\u5242\u7b26\u5408ICH\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\uff1a\u6025\u6027\u6bd2\u6027\uff08LD50\u5927\u9f20\u53e3\u670d\uff09>2000 mg\/kg\uff0c\u6f5c\u5728\u523a\u6fc0\u6027\uff08\u76ae\u80a4\/\u773c\u775b\uff09\u3002\u5904\u7406\u65f6\u9700\u9075\u5b88GHS\u5206\u7c7b\uff1aH302\uff08\u541e\u54bd\u6709\u5bb3\uff09\u3001H315\uff08\u76ae\u80a4\u523a\u6fc0\uff09\u3001H319\uff08\u773c\u523a\u6fc0\uff09\u3002\u5e9f\u5f03\u7269\u5e94\u6309\u5371\u9669\u5316\u5b66\u54c1\u89c4\u8303\u5904\u7f6e\u3002 <\/p>\n
\u6ce8\uff1a\u672c\u4ea7\u54c1\u4ec5\u9650\u79d1\u7814\u7528\u9014\uff0c\u4e0d\u53ef\u7528\u4e8e\u4eba\u4f53\u6216\u517d\u7528\u6cbb\u7597\u3002\u5177\u4f53\u5b9e\u9a8c\u65b9\u6848\u5efa\u8bae\u53c2\u8003\u6700\u65b0\u6587\u732e\u6216\u836f\u5178\u6807\u51c6\u3002<\/p>\n","protected":false},"featured_media":25953,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-49777","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/133865-89-1.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/49777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/25953"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49777"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=49777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}