N-\u82b4\u7532\u6c27\u7fb0\u57fa-N\u2019-[1-(4,4-\u4e8c\u7532\u57fa-2,6-\u4e8c\u6c27\u4ee3\u73af\u5df1\u57fa\u4e9a\u7532\u57fa)-3-\u7532\u57fa\u4e01\u57fa]-L-\u8d56\u6c28\u9178\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u5316\u5b66\u540d\u4e3a(2S)-6-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid\uff0cCAS\u53f7204777-78-6\uff0c\u5206\u5b50\u5f0fC34H42N2O6\uff0c\u5206\u5b50\u91cf574.707\u3002\u5176\u7ed3\u6784\u5305\u542b\u82b4\u7532\u6c27\u7fb0\u57fa\uff08Fmoc\uff09\u4fdd\u62a4\u57fa\u56e2\u548c\u7279\u5f02\u6027\u73af\u5df1\u4e8c\u916e\u884d\u751f\u7269\u4fee\u9970\uff0c\u7eaf\u5ea6\u7ecfHPLC\u9a8c\u8bc1\u226596%\uff0c\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u3001\u4e8c\u6c2f\u7532\u70f7\u7b49\u6709\u673a\u6eb6\u5242\uff0c\u6c34\u6eb6\u6027\u8f83\u4f4e\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3aFmoc\u4fdd\u62a4\u7684\u8d56\u6c28\u9178\u884d\u751f\u7269\uff0c\u8be5\u5316\u5408\u7269\u5728\u56fa\u76f8\u591a\u80bd\u5408\u6210\uff08SPPS\uff09\u4e2d\u5177\u6709\u5173\u952e\u4f5c\u7528\u3002\u5176\u73af\u5df1\u4e8c\u916e\u7ed3\u6784\u53ef\u9006\u6027\u4fdd\u62a4\u6c28\u57fa\uff0c\u907f\u514d\u526f\u53cd\u5e94\u53d1\u751f\uff0c\u540c\u65f6Fmoc\u57fa\u56e2\u5728\u78b1\u6027\u6761\u4ef6\u4e0b\u53ef\u9ad8\u6548\u8131\u9664\uff0c\u786e\u4fdd\u80bd\u94fe\u5ef6\u4f38\u7684\u7cbe\u51c6\u6027\u3002\u8be5\u8bbe\u8ba1\u663e\u8457\u63d0\u5347\u4e86\u957f\u80bd\u5408\u6210\u7684\u6548\u7387\u548c\u4ea7\u7269\u7eaf\u5ea6\uff0c\u7279\u522b\u9002\u7528\u4e8e\u590d\u6742\u4fee\u9970\u80bd\u6bb5\u7684\u5236\u5907\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n3.1 \u591a\u80bd\u836f\u7269\u5f00\u53d1\uff1a\u7528\u4e8e\u6784\u5efa\u542b\u8d56\u6c28\u9178\u6b8b\u57fa\u7684 therapeutic peptides\uff0c\u5982\u6297\u80bf\u7624\u80bd\u3001\u6297\u83cc\u80bd\u7b49\u3002
\n3.2 \u86cb\u767d\u8d28\u5de5\u7a0b\uff1a\u4f5c\u4e3a\u4f4d\u70b9\u7279\u5f02\u6027\u4fee\u9970\u5de5\u5177\uff0c\u5f15\u5165\u8367\u5149\u6807\u8bb0\u6216\u4ea4\u8054\u57fa\u56e2\u3002
\n3.3 \u6750\u6599\u79d1\u5b66\uff1a\u5408\u6210\u4eff\u751f\u9ad8\u5206\u5b50\u6750\u6599\uff0c\u5982\u81ea\u7ec4\u88c5\u80bd\u7eb3\u7c73\u7ea4\u7ef4\u3002
\n3.4 \u79d1\u7814\u8bd5\u5242\uff1a\u7528\u4e8e\u7814\u7a76\u86cb\u767d\u8d28-\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u53ca\u9176\u5b66\u673a\u5236\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n4.1 \u50a8\u5b58\uff1a\u5bc6\u5c01\u907f\u5149\u4fdd\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u6709\u6548\u671f24\u4e2a\u6708\u3002
\n4.2 \u6eb6\u89e3\uff1a\u63a8\u8350\u4f7f\u7528\u65e0\u6c34DMSO\u914d\u523610-50 mM\u6bcd\u6db2\uff0c\u73b0\u914d\u73b0\u7528\u3002
\n4.3 \u64cd\u4f5c\uff1a\u9700\u5728\u60f0\u6027\u6c14\u4f53\uff08\u5982\u6c2e\u6c14\uff09\u4fdd\u62a4\u4e0b\u8fdb\u884c\u654f\u611f\u53cd\u5e94\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n5.1 \u8d28\u68c0\u6807\u51c6\uff1a\u901a\u8fc7HPLC\uff08UV 254 nm\uff09\u3001\u8d28\u8c31\u53ca\u6838\u78c1\u5171\u632f\u8c31\uff08NMR\uff09\u4e09\u91cd\u9a8c\u8bc1\u3002
\n5.2 \u5b89\u5168\u8b66\u793a\uff1a\u5bf9\u773c\u775b\u548c\u547c\u5438\u9053\u6709\u8f7b\u5fae\u523a\u6fc0\u6027\uff0c\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u62a4\u76ee\u955c\u53ca\u9632\u5c18\u53e3\u7f69\u3002
\n5.3 \u5e9f\u5f03\u7269\u5904\u7406\uff1a\u6309\u5371\u9669\u6709\u673a\u5e9f\u7269\u5904\u7f6e\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u5f3a\u6c27\u5316\u5242\u3002 <\/p>\n
\u672c\u4ea7\u54c1\u4ec5\u9650\u79d1\u7814\u7528\u9014\uff0c\u4e0d\u9002\u7528\u4e8e\u4e34\u5e8a\u6216\u98df\u54c1\u9886\u57df\u3002\u5177\u4f53\u5b9e\u9a8c\u65b9\u6848\u5efa\u8bae\u53c2\u8003\u6587\u732e\uff1aJ. Pept. Sci. 2018, 24(3), e3056.<\/p>\n","protected":false},"featured_media":28722,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-49141","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/204777-78-6.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/49141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/28722"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=49141"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=49141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}