4\u03b2-\u7f9f\u57fa\u80c6\u56fa\u9187\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
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2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n4\u03b2-\u7f9f\u57fa\u80c6\u56fa\u9187\u662f\u5185\u6e90\u6027\u80c6\u56fa\u9187\u6c27\u5316\u4ea7\u7269\u4e4b\u4e00\uff0c\u5728\u8c03\u8282\u80c6\u56fa\u9187\u7a33\u6001\u548c\u7ec6\u80de\u819c\u529f\u80fd\u4e2d\u53d1\u6325\u5173\u952e\u4f5c\u7528\u3002\u5176\u6c34\u5e73\u53ef\u4f5c\u4e3aCYP3A4\u9176\u6d3b\u6027\u7684\u751f\u7269\u6807\u5fd7\u7269\uff0c\u7528\u4e8e\u8bc4\u4f30\u836f\u7269\u4ee3\u8c22\u80fd\u529b\u3002\u6b64\u5916\uff0c\u8be5\u5206\u5b50\u53c2\u4e0e\u8c03\u63a7\u809d\u810fX\u53d7\u4f53\uff08LXR\uff09\u4fe1\u53f7\u901a\u8def\uff0c\u5f71\u54cd\u8102\u8d28\u4ee3\u8c22\u3001\u708e\u75c7\u53cd\u5e94\u548c\u514d\u75ab\u8c03\u8282\u3002\u7814\u7a76\u8868\u660e\uff0c4\u03b2-\u7f9f\u57fa\u80c6\u56fa\u9187\u4e0e\u52a8\u8109\u7ca5\u6837\u786c\u5316\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u75c5\u7406\u8fc7\u7a0b\u76f8\u5173\uff0c\u662f\u7814\u7a76\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u91cd\u8981\u9776\u70b9\u5206\u5b50\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
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4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u4ea7\u54c1\u9700\u5bc6\u5c01\u4fdd\u5b58\u4e8e-20\u2103\u4ee5\u4e0b\u5e72\u71e5\u907f\u5149\u73af\u5883\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u5145\u5165\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u9700\u5e73\u8861\u81f3\u5ba4\u6e29\u540e\u5f00\u5c01\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u63a8\u8350\u4ee5DMSO\u914d\u5236\u6bcd\u6db2\uff08\u598210 mM\uff09\uff0c\u5206\u88c5\u540e\u4e8e-80\u2103\u4fdd\u5b58\uff0c\u7a00\u91ca\u65f6\u4f7f\u7528\u542b0.1%\u725b\u8840\u6e05\u767d\u86cb\u767d\uff08BSA\uff09\u7684\u7f13\u51b2\u6db2\u4ee5\u51cf\u5c11\u5438\u9644\u635f\u5931\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u751f\u7269\u5b89\u5168\u67dc\u4e2d\u8fdb\u884c\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u548c\u9ecf\u819c\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
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