1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\nConcanamycin A\uff08\u4f34\u5200\u7403\u9709\u7d20A\uff09\u662f\u4e00\u79cd\u5927\u73af\u5185\u916f\u7c7b\u6297\u751f\u7d20\uff0c\u5316\u5b66\u540d\u79f0\u4e3a(3E,5E,7S,9S,11E,13E,15R,16R)-15-[(2S,3S,4R,5S,6R)-3,4-\u4e8c\u7f9f\u57fa-6-\u7532\u57fa-5-(\u7532\u57fa\u6c28\u57fa)\u56db\u6c22-2H-\u5421\u5583-2-\u57fa]\u6c27\u57fa-16-\u4e59\u57fa-3,5,7,9,11,13-\u516d\u7532\u57fa-6,17-\u4e8c\u6c27\u6742\u53cc\u73af[13.1.0]\u5341\u516d\u78b3-3,5,11,13-\u56db\u70ef-4-\u916e\u3002\u5176CAS\u53f7\u4e3a80890-47-7\uff0c\u5206\u5b50\u5f0f\u4e3aC46H75NO14\uff0c\u5206\u5b50\u91cf\u4e3a866.09\u3002\u672c\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7c89\u672b\uff0c\u7eaf\u5ea6\u5927\u4e8e96%\uff0c\u6613\u6eb6\u4e8e\u6709\u673a\u6eb6\u5242\uff08\u5982DMSO\u3001\u7532\u9187\uff09\uff0c\u5fae\u6eb6\u4e8e\u6c34\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\nConcanamycin A\u662f\u4e00\u79cd\u7279\u5f02\u6027V-ATP\u9176\u6291\u5236\u5242\uff0c\u901a\u8fc7\u9009\u62e9\u6027\u963b\u65ad\u6db2\u6ce1\u578bH+-ATPase\u7684\u8d28\u5b50\u6cf5\u529f\u80fd\uff0c\u5e72\u6270\u7ec6\u80de\u5185pH\u8c03\u8282\u548c\u6eb6\u9176\u4f53\u529f\u80fd\u3002\u5176\u5728\u7814\u7a76\u4e2d\u5e7f\u6cdb\u5e94\u7528\u4e8e\u63a2\u7d22\u7ec6\u80de\u81ea\u566c\u3001\u5185\u541e\u4f5c\u7528\u53ca\u6eb6\u9176\u4f53\u76f8\u5173\u4ee3\u8c22\u9014\u5f84\u7684\u8c03\u63a7\u673a\u5236\u3002\u7531\u4e8e\u5176\u9ad8\u6548\u6027\u548c\u7279\u5f02\u6027\uff0c\u8be5\u5316\u5408\u7269\u5df2\u6210\u4e3a\u7814\u7a76\u80bf\u7624\u5fae\u73af\u5883\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u53ca\u75c5\u539f\u4f53\u611f\u67d3\u673a\u5236\u7684\u91cd\u8981\u5de5\u5177\u5206\u5b50\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\nConcanamycin A\u5728\u4ee5\u4e0b\u9886\u57df\u5177\u6709\u91cd\u8981\u5e94\u7528\uff1a
\n– \u80bf\u7624\u7814\u7a76\uff1a\u901a\u8fc7\u6291\u5236V-ATP\u9176\uff0c\u5e72\u6270\u80bf\u7624\u7ec6\u80de\u7684\u9178\u6027\u5fae\u73af\u5883\uff0c\u6291\u5236\u5176\u4fb5\u88ad\u548c\u8f6c\u79fb\u3002
\n– \u514d\u75ab\u5b66\uff1a\u7814\u7a76\u6eb6\u9176\u4f53\u5728\u6297\u539f\u5448\u9012\u548c\u514d\u75ab\u5e94\u7b54\u4e2d\u7684\u4f5c\u7528\u3002
\n– \u5fae\u751f\u7269\u5b66\uff1a\u63a2\u7a76\u75c5\u539f\u4f53\uff08\u5982\u7ed3\u6838\u5206\u679d\u6746\u83cc\uff09\u5229\u7528\u5bbf\u4e3b\u6eb6\u9176\u4f53\u9003\u9038\u7684\u673a\u5236\u3002
\n– \u795e\u7ecf\u79d1\u5b66\uff1a\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u75be\u75c5\u4e2d\u81ea\u566c-\u6eb6\u9176\u4f53\u901a\u8def\u5f02\u5e38\u7684\u7814\u7a76\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u672c\u54c1\u9700\u907f\u5149\u4fdd\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u7f6e\u4e8e\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4e0b\u3002\u4f7f\u7528\u65f6\u5efa\u8bae\u4ee5DMSO\u914d\u5236\u6bcd\u6db2\uff08\u598210 mM\uff09\uff0c\u5206\u88c5\u540e\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5de5\u4f5c\u6d53\u5ea6\u9700\u6839\u636e\u5b9e\u9a8c\u4f53\u7cfb\u4f18\u5316\uff0c\u5e38\u7528\u8303\u56f4\u4e3a10-100 nM\u3002\u6ce8\u610f\uff1aConcanamycin A\u5bf9\u5149\u654f\u611f\uff0c\u64cd\u4f5c\u65f6\u5e94\u907f\u5149\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u7ecfHPLC\u9a8c\u8bc1\u7eaf\u5ea6>96%\uff0c\u5e76\u901a\u8fc7\u8d28\u8c31\u548c\u6838\u78c1\u5171\u632f\u786e\u8ba4\u7ed3\u6784\u3002\u4f7f\u7528\u65f6\u9700\u7a7f\u6234\u9632\u62a4\u88c5\u5907\uff08\u624b\u5957\u3001\u62a4\u76ee\u955c\uff09\uff0c\u907f\u514d\u5438\u5165\u6216\u76ae\u80a4\u63a5\u89e6\u3002\u5176\u534a\u6570\u81f4\u6b7b\u91cf\uff08LD50\uff09\u5728\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04\u6a21\u578b\u4e2d\u4e3a1.2 mg\/kg\uff0c\u63d0\u793a\u9ad8\u6bd2\u6027\u3002\u5e9f\u5f03\u7269\u5e94\u4f5c\u4e3a\u6709\u5bb3\u5316\u5b66\u7269\u8d28\u5904\u7406\uff0c\u9075\u5b88\u5f53\u5730\u6cd5\u89c4\u3002 <\/p>\n
\uff08\u6ce8\uff1a\u4ee5\u4e0a\u8bf4\u660e\u57fa\u4e8e\u73b0\u6709\u7814\u7a76\u6570\u636e\uff0c\u5177\u4f53\u5e94\u7528\u9700\u7ed3\u5408\u5b9e\u9a8c\u6761\u4ef6\u4f18\u5316\u3002\uff09<\/p>\n","protected":false},"featured_media":35818,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-47897","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/80890-47-7.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/47897","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/35818"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47897"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=47897"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}