1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u9664\u83a0\u9709\u7d20A\uff08Herbimycin A\uff09\u662f\u4e00\u79cd\u6765\u6e90\u4e8e\u94fe\u9709\u83cc\uff08Streptomyces hygroscopicus\uff09\u7684\u82ef\u918c\u5b89\u838e\u9709\u7d20\u7c7b\u6297\u751f\u7d20\uff0c\u5316\u5b66\u540d\u79f0\u4e3a19-(3-\u7532\u57fa-2-\u4e01\u70ef\u57fa)-\u683c\u5c14\u5fb7\u9709\u7d20\u3002\u5176CAS\u53f7\u4e3a70563-58-5\uff0c\u5206\u5b50\u5f0f\u4e3aC30H42N2O9\uff0c\u5206\u5b50\u91cf\u4e3a574.662\u3002\u672c\u54c1\u4e3a\u9ec4\u8272\u81f3\u68d5\u8272\u7c89\u672b\uff0c\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u53ef\u6eb6\u4e8eDMSO\u3001\u7532\u9187\u7b49\u6709\u673a\u6eb6\u5242\uff0c\u5fae\u6eb6\u4e8e\u6c34\u3002\u9664\u83a0\u9709\u7d20A\u4ee5\u5176\u72ec\u7279\u7684\u5b89\u838e\u9709\u7d20\u7ed3\u6784\uff0c\u8868\u73b0\u51fa\u663e\u8457\u7684\u70ed\u4f11\u514b\u86cb\u767d90\uff08Hsp90\uff09\u6291\u5236\u6d3b\u6027\uff0c\u662f\u7814\u7a76\u86cb\u767d\u8d28\u6298\u53e0\u4e0e\u964d\u89e3\u7684\u91cd\u8981\u5de5\u5177\u5206\u5b50\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u9664\u83a0\u9709\u7d20A\u901a\u8fc7\u7279\u5f02\u6027\u7ed3\u5408Hsp90\u7684ATP\u7ed3\u5408\u4f4d\u70b9\uff0c\u6291\u5236\u5176\u5206\u5b50\u4f34\u4fa3\u529f\u80fd\uff0c\u5bfc\u81f4\u5ba2\u6237\u86cb\u767d\uff08\u5982\u6fc0\u9176\u3001\u8f6c\u5f55\u56e0\u5b50\u7b49\uff09\u7684\u6cdb\u7d20\u5316\u964d\u89e3\u3002\u8fd9\u4e00\u673a\u5236\u4f7f\u5176\u6210\u4e3a\u7814\u7a76\u80bf\u7624\u53d1\u751f\u3001\u4fe1\u53f7\u8f6c\u5bfc\u548c\u86cb\u767d\u8d28\u7a33\u6001\u7684\u5173\u952e\u63a2\u9488\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u80fd\u6291\u5236Src\u5bb6\u65cf\u6fc0\u9176\u6d3b\u6027\uff0c\u5728\u708e\u75c7\u548c\u514d\u75ab\u8c03\u8282\u7814\u7a76\u4e2d\u5177\u6709\u5e7f\u6cdb\u5e94\u7528\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u9664\u83a0\u9709\u7d20A\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5206\u5b50\u751f\u7269\u5b66\u548c\u836f\u7406\u5b66\u7814\u7a76\uff0c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a
\n– \u764c\u75c7\u7814\u7a76\uff1a\u7528\u4e8e\u63a2\u7a76Hsp90\u6291\u5236\u5242\u5bf9\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u3001\u51cb\u4ea1\u7684\u5f71\u54cd\u3002
\n– \u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff1a\u7814\u7a76\u9519\u8bef\u6298\u53e0\u86cb\u767d\u7684\u6e05\u9664\u673a\u5236\u3002
\n– \u5fae\u751f\u7269\u5b66\uff1a\u4f5c\u4e3a\u6297\u751f\u7d20\u8010\u836f\u6027\u7814\u7a76\u7684\u5de5\u5177\u5316\u5408\u7269\u3002
\n– \u7ec6\u80de\u4fe1\u53f7\u8f6c\u5bfc\uff1a\u5206\u6790\u6fc0\u9176\u4f9d\u8d56\u6027\u901a\u8def\uff08\u5982PI3K\/Akt\u3001MAPK\uff09\u7684\u8c03\u63a7\u673a\u5236\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u672c\u54c1\u9700\u907f\u5149\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u5145\u5165\u60f0\u6027\u6c14\u4f53\u3002\u4f7f\u7528\u524d\u9700\u5e73\u8861\u81f3\u5ba4\u6e29\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5de5\u4f5c\u6d53\u5ea6\u901a\u5e38\u4e3a0.1-10 \u03bcM\uff08\u9700\u6839\u636e\u5b9e\u9a8c\u4f53\u7cfb\u4f18\u5316\uff09\uff0c\u5efa\u8bae\u7528DMSO\u914d\u5236\u6bcd\u6db2\uff08\u598210 mM\uff09\uff0c\u5e76\u7528\u7f13\u51b2\u6db2\u7a00\u91ca\u81f3\u7ec8\u6d53\u5ea6\uff08DMSO\u542b\u91cf\u4e0d\u8d85\u8fc70.1%\uff09\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u7ecfHPLC\u9a8c\u8bc1\u7eaf\u5ea6>96%\uff0c\u5e76\u901a\u8fc7\u8d28\u8c31\u548c\u6838\u78c1\u5171\u632f\u786e\u8ba4\u7ed3\u6784\u3002\u4f7f\u7528\u65f6\u9700\u7a7f\u6234\u9632\u62a4\u88c5\u5907\uff08\u624b\u5957\u3001\u62a4\u76ee\u955c\u7b49\uff09\uff0c\u907f\u514d\u5438\u5165\u6216\u63a5\u89e6\u76ae\u80a4\u3002\u5176\u534a\u6570\u81f4\u6b7b\u5242\u91cf\uff08LD50\uff09\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04\u4e3a25 mg\/kg\uff0c\u5c5e\u4e8e\u6709\u5bb3\u5316\u5408\u7269\uff0c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u64cd\u4f5c\u3002\u5e9f\u5f03\u7269\u5e94\u6309\u7167\u5371\u9669\u5316\u5b66\u54c1\u89c4\u8303\u5904\u7f6e\u3002<\/p>\n","protected":false},"featured_media":34935,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-47741","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/70563-58-5.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/47741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/34935"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47741"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=47741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}