3-(4-\u7532\u57fa-1-\u54cc\u55ea\u57fa)-4-\u7532\u781c\u57fa\u82ef\u7532\u9178\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u5316\u5b66\u540d\u79f0\u4e3a3-(4-Methyl-1-piperazinyl)-4-(methylsulfonyl)benzoic Acid\uff0c\u5206\u5b50\u5f0fC13H18N2O4S\uff0c\u5206\u5b50\u91cf298.358\uff0cCAS\u53f71197193-05-7\u3002\u5176\u7ed3\u6784\u4e2d\u540c\u65f6\u542b\u6709\u54cc\u55ea\u73af\u3001\u7532\u781c\u57fa\u548c\u82ef\u7532\u9178\u57fa\u56e2\uff0c\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u6781\u6027\u548c\u4e24\u4eb2\u6027\uff0c\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u548c\u7532\u9187\uff0c\u5fae\u6eb6\u4e8e\u6c34\uff08pH>7\u65f6\u6eb6\u89e3\u5ea6\u589e\u52a0\uff09\u3002\u7eaf\u5ea6\u7ecfHPLC\u9a8c\u8bc1\u226596%\uff0c\u7b26\u5408\u751f\u5316\u8bd5\u5242\u6807\u51c6\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
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3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u5728\u836f\u7269\u7814\u53d1\u4e2d\uff0c\u672c\u54c1\u5e38\u7528\u4e8e\u6784\u5efaEGFR\u3001ALK\u7b49\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\u7684\u5148\u5bfc\u5316\u5408\u7269\u3002\u4f53\u5916\u5b9e\u9a8c\u663e\u793a\u5176\u5bf9\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7ec6\u80de\u682a\u7684\u589e\u6b96\u6291\u5236\u6d3b\u6027\uff08IC50\u53ef\u8fbe\u5fae\u6469\u5c14\u7ea7\uff09\u3002\u4ea6\u53ef\u4f5c\u4e3a\u8367\u5149\u6807\u8bb0\u63a2\u9488\u7684\u4e2d\u95f4\u4f53\uff0c\u7528\u4e8e\u6d3b\u7ec6\u80de\u6210\u50cf\u7814\u7a76\u3002\u5de5\u4e1a\u9886\u57df\u53ef\u7528\u4e8e\u7279\u79cd\u9ad8\u5206\u5b50\u6750\u6599\u7684\u6539\u6027\u5355\u4f53\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u63a8\u8350\u907f\u5149\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u5f00\u5c01\u540e\u9700\u5145\u6c2e\u5bc6\u5c01\u3002\u6eb6\u6db2\u914d\u5236\u5efa\u8bae\u4f7f\u7528\u9884\u51b7\u7684\u65e0\u6c34DMSO\uff08\u6d53\u5ea6\u226410mM\uff09\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\uff0c\u4e0e\u5f3a\u6c27\u5316\u5242\u9694\u79bb\u5b58\u653e\u3002\u6c34\u6eb6\u6db2\u4f53\u7cfb\u5efa\u8bae\u73b0\u914d\u73b0\u7528\uff0cpH\u9700\u7a33\u5b9a\u57286.5-7.5\u533a\u95f4\u4ee5\u9632\u964d\u89e3\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u6bcf\u6279\u6b21\u4ea7\u54c1\u5747\u63d0\u4f9bCOA\u62a5\u544a\uff0c\u5305\u542bHPLC\u7eaf\u5ea6\u3001\u6c34\u5206\u542b\u91cf\uff08KF\u6cd5\u22640.5%\uff09\u3001\u91cd\u91d1\u5c5e\u6b8b\u7559\uff08\u226410ppm\uff09\u7b49\u6570\u636e\u3002\u6025\u6027\u6bd2\u6027\u5b9e\u9a8c\u663e\u793a\u5176LD50\uff08\u5927\u9f20\u53e3\u670d\uff09>500mg\/kg\uff0c\u4f46\u63a5\u89e6\u76ae\u80a4\u53ef\u80fd\u5f15\u8d77\u8f7b\u5fae\u523a\u6fc0\uff0c\u64cd\u4f5c\u65f6\u5e94\u4f69\u6234\u4e01\u8148\u624b\u5957\u548c\u62a4\u76ee\u955c\u3002\u5e9f\u5f03\u7269\u5904\u7f6e\u9700\u7b26\u5408\u5371\u9669\u6709\u673a\u5316\u5408\u7269\u5904\u7406\u89c4\u8303\u3002 <\/p>\n
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