1-{2-[2-\u7f9f\u57fa-3-(1-\u54cc\u5576\u57fa)\u4e19\u6c27\u57fa]\u82ef\u57fa}-3-\u82ef\u57fa-1-\u4e19\u916e\uff08\u805a\u786b\u6a61\u80f6\uff09\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u5316\u5b66\u540d\u79f0\u4e3a1-{2-[2-Hydroxy-3-(1-piperidinyl)propoxy]phenyl}-3-phenyl-1-propanone\uff0c\u4e2d\u6587\u901a\u7528\u540d\u4e3a\u805a\u786b\u6a61\u80f6\uff0cCAS\u53f7\u4e3a63148-67-4\u3002\u5176\u5206\u5b50\u5f0f\u4e3aC23H29NO3\uff0c\u5206\u5b50\u91cf\u4e3a367.481\uff0c\u7eaf\u5ea6\u7ecf\u9ad8\u6548\u6db2\u76f8\u8272\u8c31\uff08HPLC\uff09\u6d4b\u5b9a\u5927\u4e8e96%\u3002\u8be5\u5316\u5408\u7269\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u53ef\u6eb6\u4e8e\u6709\u673a\u6eb6\u5242\u5982\u7532\u9187\u3001\u4e59\u9187\u53ca\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\uff0c\u5fae\u6eb6\u4e8e\u6c34\u3002\u5176\u7ed3\u6784\u4e2d\u7684\u54cc\u5576\u57fa\u4e0e\u82ef\u4e19\u916e\u9aa8\u67b6\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u5316\u5b66\u6d3b\u6027\uff0c\u9002\u7528\u4e8e\u591a\u79cd\u6709\u673a\u5408\u6210\u53ca\u751f\u7269\u5316\u5b66\u7814\u7a76\u573a\u666f\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u805a\u786b\u6a61\u80f6\u4f5c\u4e3a\u4e00\u79cd\u542b\u6c2e\u6742\u73af\u5316\u5408\u7269\uff0c\u53ef\u901a\u8fc7\u5176\u54cc\u5576\u57fa\u56e2\u53c2\u4e0e\u914d\u4f4d\u53cd\u5e94\uff0c\u540c\u65f6\u7f9f\u57fa\u4e0e\u916e\u57fa\u7ed3\u6784\u4f7f\u5176\u6210\u4e3a\u836f\u7269\u4e2d\u95f4\u4f53\u5408\u6210\u4e2d\u7684\u91cd\u8981\u6a21\u5757\u3002\u7814\u7a76\u8868\u660e\uff0c\u8be5\u5206\u5b50\u5728\u8c03\u63a7\u9176\u6d3b\u6027\u53ca\u8de8\u819c\u4fe1\u53f7\u4f20\u5bfc\u4e2d\u5177\u6709\u4e00\u5b9a\u6f5c\u529b\uff0c\u5c24\u5176\u5728\u795e\u7ecf\u79d1\u5b66\u548c\u6297\u708e\u836f\u7269\u7814\u53d1\u9886\u57df\u53d7\u5230\u5173\u6ce8\u3002\u5176\u9ad8\u7eaf\u5ea6\u7279\u6027\u786e\u4fdd\u4e86\u5b9e\u9a8c\u6570\u636e\u7684\u53ef\u91cd\u590d\u6027\uff0c\u662f\u57fa\u7840\u7814\u7a76\u4e0e\u5de5\u4e1a\u5316\u751f\u4ea7\u7684\u7406\u60f3\u9009\u62e9\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u8be5\u4ea7\u54c1\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a
\n\uff081\uff09\u533b\u836f\u4e2d\u95f4\u4f53\uff1a\u7528\u4e8e\u5408\u6210\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u54cc\u5576\u7c7b\u884d\u751f\u7269\uff1b
\n\uff082\uff09\u6750\u6599\u79d1\u5b66\uff1a\u4f5c\u4e3a\u4ea4\u8054\u5242\u53c2\u4e0e\u9ad8\u5206\u5b50\u805a\u5408\u7269\uff08\u5982\u529f\u80fd\u6027\u6a61\u80f6\uff09\u7684\u5236\u5907\uff1b
\n\uff083\uff09\u751f\u5316\u7814\u7a76\uff1a\u7528\u4e8e\u9176\u6291\u5236\u5b9e\u9a8c\u6216\u53d7\u4f53\u7ed3\u5408\u8bd5\u9a8c\u7684\u5bf9\u7167\u54c1\uff1b
\n\uff084\uff09\u5de5\u4e1a\u50ac\u5316\uff1a\u5728\u4e0d\u5bf9\u79f0\u5408\u6210\u4e2d\u4f5c\u4e3a\u624b\u6027\u52a9\u5242\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u50a8\u5b58\u4e8e\u5bc6\u95ed\u5bb9\u5668\u4e2d\uff0c\u653e\u7f6e\u4e8e-20\u00b0C\u5e72\u71e5\u907f\u5149\u73af\u5883\uff0c\u907f\u514d\u4e0e\u5f3a\u6c27\u5316\u5242\u63a5\u89e6\u3002\u5f00\u5c01\u540e\u9700\u5145\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u4ee5\u5ef6\u957f\u7a33\u5b9a\u6027\u3002\u4f7f\u7528\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u3001\u62a4\u76ee\u955c\u53ca\u5b9e\u9a8c\u670d\uff0c\u5728\u901a\u98ce\u6a71\u4e2d\u64cd\u4f5c\u3002\u6eb6\u89e3\u63a8\u8350\u4f7f\u7528\u5206\u6790\u7ea7DMSO\uff0c\u914d\u5236\u6eb6\u6db2\u5efa\u8bae\u73b0\u914d\u73b0\u7528\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002 <\/p>\n
5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u7ecf\u8d28\u8c31\uff08MS\uff09\u53ca\u6838\u78c1\u5171\u632f\uff08NMR\uff09\u9a8c\u8bc1\u7ed3\u6784\uff0c\u6279\u6b21\u95f4\u7eaf\u5ea6\u5dee\u5f02\u5c0f\u4e8e1%\u3002\u5b89\u5168\u6570\u636e\u8868\u660e\uff0c\u5176\u6025\u6027\u6bd2\u6027\uff08LD50\uff09\u4e3a\u5927\u9f20\u7ecf\u53e3>500 mg\/kg\uff0c\u5c5e\u4e8e\u4f4e\u6bd2\u7c7b\u5316\u5408\u7269\uff0c\u4f46\u53ef\u80fd\u5bf9\u773c\u775b\u548c\u76ae\u80a4\u4ea7\u751f\u8f7b\u5fae\u523a\u6fc0\u3002\u5e9f\u5f03\u5904\u7406\u9700\u9075\u5faa\u5f53\u5730\u5316\u5b66\u54c1\u7ba1\u7406\u6cd5\u89c4\uff0c\u4e0d\u53ef\u76f4\u63a5\u6392\u5165\u4e0b\u6c34\u9053\u3002 <\/p>\n
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