Boc-N’-(2-\u6c2f\u82c4\u6c27\u7fb0\u57fa)-D-\u8d56\u6c28\u9178\u4ea7\u54c1\u8bf4\u660e\u4e66 <\/p>\n
1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\nBoc-N’-(2-chloro-Cbz)-D-lysine\u662f\u4e00\u79cd\u9ad8\u7eaf\u5ea6\u4fdd\u62a4\u6c28\u57fa\u9178\u884d\u751f\u7269\uff0c\u5316\u5b66\u540d\u79f0\u4e3a\u53d4\u4e01\u6c27\u7fb0\u57fa-N’-(2-\u6c2f\u82c4\u6c27\u7fb0\u57fa)-D-\u8d56\u6c28\u9178\uff0cCAS\u53f7\u4e3a57096-11-4\u3002\u5176\u5206\u5b50\u5f0f\u4e3aC19H27ClN2O6\uff0c\u5206\u5b50\u91cf\u4e3a414.88\uff0c\u5e38\u6e29\u4e0b\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\u3002\u8be5\u5316\u5408\u7269\u540c\u65f6\u542b\u6709Boc\uff08\u53d4\u4e01\u6c27\u7fb0\u57fa\uff09\u548c2-\u6c2f-Cbz\uff082-\u6c2f\u82c4\u6c27\u7fb0\u57fa\uff09\u53cc\u91cd\u4fdd\u62a4\u57fa\u56e2\uff0c\u53ef\u9009\u62e9\u6027\u8131\u4fdd\u62a4\uff0c\u9002\u7528\u4e8e\u591a\u80bd\u56fa\u76f8\u5408\u6210\u4e2d\u7684\u6b63\u4ea4\u4fdd\u62a4\u7b56\u7565\u3002 <\/p>\n
2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3aD-\u6784\u578b\u8d56\u6c28\u9178\u7684\u884d\u751f\u7269\uff0c\u8be5\u4ea7\u54c1\u5728\u591a\u80bd\u836f\u7269\u5f00\u53d1\u4e2d\u5177\u6709\u7279\u6b8a\u4ef7\u503c\u3002\u5176\u624b\u6027\u4e2d\u5fc3\u53ef\u8d4b\u4e88\u591a\u80bd\u7279\u5b9a\u7684\u7a7a\u95f4\u6784\u8c61\uff0c\u800c\u6c2f\u539f\u5b50\u7684\u5f15\u5165\u589e\u5f3a\u4e86Cbz\u4fdd\u62a4\u57fa\u7684\u7a33\u5b9a\u6027\u3002\u5728\u7cd6\u80bd\u7c7b\u6297\u751f\u7d20\uff08\u5982\u4e07\u53e4\u9709\u7d20\u7c7b\u4f3c\u7269\uff09\u5408\u6210\u4e2d\uff0c\u6b64\u7c7b\u4fee\u9970\u6c28\u57fa\u9178\u80fd\u6709\u6548\u8c03\u63a7\u5206\u5b50\u95f4\u76f8\u4e92\u4f5c\u7528\uff0c\u63d0\u9ad8\u76ee\u6807\u4ea7\u7269\u7684\u751f\u7269\u6d3b\u6027\u4e0e\u4ee3\u8c22\u7a33\u5b9a\u6027\u3002 <\/p>\n
3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u4ea7\u54c1\u4e3b\u8981\u5e94\u7528\u4e8e\u4ee5\u4e0b\u9886\u57df\uff1a
\n3.1 \u591a\u80bd\u836f\u7269\u7814\u53d1\uff1a\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\u7528\u4e8e\u5408\u6210\u542bD-\u8d56\u6c28\u9178\u7ed3\u6784\u7684\u6cbb\u7597\u6027\u591a\u80bd\uff0c\u5982\u6297\u83cc\u80bd\u3001\u6fc0\u7d20\u7c7b\u4f3c\u7269\u7b49\u3002
\n3.2 PROTAC\u5206\u5b50\u6784\u5efa\uff1a\u901a\u8fc7\u03b5-\u6c28\u57fa\u7684\u5b9a\u5411\u4fee\u9970\uff0c\u53c2\u4e0e\u9776\u5411\u86cb\u767d\u964d\u89e3\u5242\u7684 linker \u8bbe\u8ba1\u3002
\n3.3 \u6750\u6599\u79d1\u5b66\uff1a\u7528\u4e8e\u529f\u80fd\u5316\u9ad8\u5206\u5b50\u6750\u6599\u7684\u5355\u4f53\u5408\u6210\uff0c\u5982\u751f\u7269\u76f8\u5bb9\u6027\u6c34\u51dd\u80f6\u7684\u5236\u5907\u3002 <\/p>\n
4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5728-20\u2103\u5e72\u71e5\u907f\u5149\u6761\u4ef6\u4e0b\u957f\u671f\u50a8\u5b58\uff0c\u5f00\u5c01\u540e\u9700\u5145\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u3002\u4f7f\u7528\u524d\u9700\u6062\u590d\u81f3\u5ba4\u6e29\u5e76\u4fdd\u6301\u73af\u5883\u5e72\u71e5\uff08\u76f8\u5bf9\u6e7f\u5ea6<40%\uff09\u3002\u6eb6\u89e3\u6027\u6d4b\u8bd5\u8868\u660e\uff0c\u8be5\u5316\u5408\u7269\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u3001\u4e8c\u6c2f\u7532\u70f7\u7b49\u6709\u673a\u6eb6\u5242\uff0c\u5728\u6c34\u6eb6\u6db2\u4e2d\u6eb6\u89e3\u5ea6\u8f83\u4f4e\u3002\u5b9e\u9a8c\u64cd\u4f5c\u5efa\u8bae\u5728\u901a\u98ce\u6a71\u4e2d\u8fdb\u884c\u3002 \n\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f \n\u672c\u4ea7\u54c1\u7ecfHPLC\u68c0\u6d4b\u7eaf\u5ea6>96%\uff0c\u7b26\u5408\u836f\u7269\u7814\u53d1\u7ea7\u6807\u51c6\u3002MS\u548cNMR\u8c31\u56fe\u6570\u636e\u53ef\u968f\u8d27\u63d0\u4f9b\u3002\u5b89\u5168\u6ce8\u610f\u4e8b\u9879\uff1a
\n5.1 \u907f\u514d\u4e0e\u76ae\u80a4\u3001\u773c\u775b\u76f4\u63a5\u63a5\u89e6\uff0c\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u88c5\u5907\u3002
\n5.2 \u9047\u5f3a\u9178\u5f3a\u78b1\u53ef\u80fd\u91ca\u653e\u6709\u6bd2\u6c14\u4f53\uff0c\u9700\u907f\u514d\u4e0e\u8150\u8680\u6027\u7269\u8d28\u5171\u5b58\u3002
\n5.3 \u5e9f\u5f03\u7269\u5e94\u6309\u7167\u5371\u9669\u6709\u673a\u5316\u5b66\u54c1\u5904\u7f6e\u89c4\u8303\u5904\u7406\u3002 <\/p>\n
\uff08\u6ce8\uff1a\u672c\u8bf4\u660e\u57fa\u4e8e\u5f53\u524d\u7814\u7a76\u6570\u636e\u7f16\u5236\uff0c\u5177\u4f53\u5e94\u7528\u9700\u7ed3\u5408\u5b9e\u9a8c\u6761\u4ef6\u4f18\u5316\u3002\u6280\u672f\u53c2\u6570\u66f4\u65b0\u6055\u4e0d\u53e6\u884c\u901a\u77e5\u3002\uff09<\/p>\n","protected":false},"featured_media":33332,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[25],"class_list":["post-47154","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-25"],"acf":[],"taxonomy_info":{"product_category":[{"value":25,"label":"\u5b9e\u9a8c\u836f\u54c1"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/57096-11-4.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/47154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/33332"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=47154"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=47154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}