{"id":23011,"date":"2026-04-01T18:43:37","date_gmt":"2026-04-01T10:43:37","guid":{"rendered":"http:\/\/111.62.156.167\/index.php\/product\/%e5%b0%bc%e7%bd%97%e6%9b%bf%e5%b0%bc\/"},"modified":"2026-04-01T22:26:14","modified_gmt":"2026-04-01T14:26:14","slug":"%e5%b0%bc%e7%bd%97%e6%9b%bf%e5%b0%bc","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=%e5%b0%bc%e7%bd%97%e6%9b%bf%e5%b0%bc","title":{"rendered":"\u5c3c\u7f57\u66ff\u5c3c"},"content":{"rendered":"<p>\u4ea7\u54c1\u8bf4\u660e<br \/>\n\u5c3c\u7f57\u66ff\u5c3c\uff08Nilotinib\uff09\u4ea7\u54c1\u8bf4\u660e<br \/>\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027<br \/>\n\u5c3c\u7f57\u66ff\u5c3c\uff08\u5316\u5b66\u540d\u79f0\uff1anilotinib\uff0cCAS\u53f7\uff1a641571-10-0\uff09\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5176\u5206\u5b50\u5f0f\u4e3aC28H22F3N7O\uff0c\u5206\u5b50\u91cf\u4e3a529.516\u3002\u672c\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5177\u6709\u826f\u597d\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u548c\u6eb6\u89e3\u6027\uff08\u6eb6\u4e8eDMSO\u3001\u7532\u9187\u7b49\u6709\u673a\u6eb6\u5242\uff09\u3002\u5c3c\u7f57\u66ff\u5c3c\u901a\u8fc7\u7279\u5f02\u6027\u9776\u5411Bcr-Abl\u6fc0\u9176\u53d1\u6325\u836f\u7406\u4f5c\u7528\uff0c\u662f\u7b2c\u4e8c\u4ee3\u9776\u5411\u6297\u764c\u836f\u7269\u7684\u91cd\u8981\u4ee3\u8868\u4e4b\u4e00\u3002<br \/>\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027<br \/>\n\u5c3c\u7f57\u66ff\u5c3c\u901a\u8fc7\u7ade\u4e89\u6027\u7ed3\u5408Bcr-Abl\u6fc0\u9176\u7684ATP\u7ed3\u5408\u4f4d\u70b9\uff0c\u6291\u5236\u5176\u5f02\u5e38\u6fc0\u6d3b\uff0c\u4ece\u800c\u963b\u65ad\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\uff08\u5982JAK\/STAT\u3001PI3K\/AKT\u7b49\uff09\uff0c\u6709\u6548\u6291\u5236\u767d\u8840\u75c5\u7ec6\u80de\u7684\u589e\u6b96\u4e0e\u5b58\u6d3b\u3002\u4e0e\u7b2c\u4e00\u4ee3\u6291\u5236\u5242\u76f8\u6bd4\uff0c\u5c3c\u7f57\u66ff\u5c3c\u5bf9Bcr-Abl\u7684\u4eb2\u548c\u529b\u66f4\u9ad8\uff0c\u4e14\u80fd\u514b\u670d\u90e8\u5206\u8010\u836f\u7a81\u53d8\uff08\u5982Y253H\u3001E255K\u7b49\uff09\uff0c\u5728\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08CML\uff09\u6cbb\u7597\u4e2d\u5177\u6709\u663e\u8457\u4e34\u5e8a\u4ef7\u503c\u3002<br \/>\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014<br \/>\n\u5c3c\u7f57\u66ff\u5c3c\u4e3b\u8981\u7528\u4e8e\u6cbb\u7597\u8d39\u57ce\u67d3\u8272\u4f53\u9633\u6027\uff08Ph+\uff09\u7684\u6162\u6027\u9ad3\u6027\u767d\u8840\u75c5\uff08CML\uff09\u60a3\u8005\uff0c\u5c24\u5176\u9002\u7528\u4e8e\u5bf9\u4f0a\u9a6c\u66ff\u5c3c\u8010\u836f\u6216\u4e0d\u8010\u53d7\u7684\u75c5\u4f8b\u3002\u6b64\u5916\uff0c\u7814\u7a76\u663e\u793a\u5176\u5728\u80c3\u80a0\u9053\u95f4\u8d28\u7624\uff08GIST\uff09\u548c\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u4e5f\u6709\u6f5c\u5728\u5e94\u7528\u3002\u5b9e\u9a8c\u5ba4\u4e2d\uff0c\u5c3c\u7f57\u66ff\u5c3c\u5e38\u4f5c\u4e3aBcr-Abl\u4fe1\u53f7\u901a\u8def\u7814\u7a76\u7684\u5de5\u5177\u5316\u5408\u7269\uff0c\u7528\u4e8e\u836f\u7269\u7b5b\u9009\u6216\u673a\u5236\u63a2\u7d22\u3002<br \/>\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae<br \/>\n\u672c\u54c1\u9700\u907f\u5149\u4fdd\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u5145\u6c2e\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u9700\u5728\u65e0\u83cc\u6761\u4ef6\u4e0b\u64cd\u4f5c\uff0c\u63a8\u8350\u4ee5DMSO\u914d\u5236\u6bcd\u6db2\uff08\u6d53\u5ea6\u226410 mM\uff09\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u5de5\u4f5c\u6d53\u5ea6\u9700\u6839\u636e\u5b9e\u9a8c\u4f53\u7cfb\u4f18\u5316\uff0c\u7ec6\u80de\u5b9e\u9a8c\u5e38\u7528\u8303\u56f4\u4e3a10-100 nM\u3002\u6ce8\u610f\uff1a\u5c3c\u7f57\u66ff\u5c3c\u5bf9\u4eba\u4f53\u6709\u5bb3\uff0c\u64cd\u4f5c\u65f6\u9700\u7a7f\u6234\u9632\u62a4\u88c5\u5907\u3002<br \/>\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f<br \/>\n\u672c\u4ea7\u54c1\u7ecfHPLC\u68c0\u6d4b\u7eaf\u5ea6>96%\uff0c\u7b26\u5408\u79d1\u7814\u7ea7\u6807\u51c6\u3002MS\u548cNMR\u8c31\u56fe\u53ef\u63d0\u4f9b\u9a8c\u8bc1\u3002\u5b89\u5168\u4fe1\u606f\uff1a\u6025\u6027\u6bd2\u6027\uff08\u53e3\u670d\uff0c\u5927\u9f20LD50>2000 mg\/kg\uff09\uff0c\u53ef\u80fd\u5f15\u8d77\u773c\u775b\u548c\u76ae\u80a4\u523a\u6fc0\u3002\u4f7f\u7528\u65f6\u9700\u9075\u5b88\u5b9e\u9a8c\u5ba4\u5b89\u5168\u89c4\u8303\uff0c\u5e9f\u5f03\u7269\u6309\u5371\u9669\u5316\u5b66\u54c1\u5904\u7406\u3002\u907f\u514d\u5438\u5165\u6216\u76f4\u63a5\u63a5\u89e6\uff0c\u5982\u610f\u5916\u66b4\u9732\u9700\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u5e76\u5c31\u533b\u3002<br \/>\n\uff08\u6ce8\uff1a\u672c\u8bf4\u660e\u4ec5\u9650\u79d1\u7814\u7528\u9014\uff0c\u4e0d\u9002\u7528\u4e8e\u4e34\u5e8a\u8bca\u65ad\u6216\u6cbb\u7597\u3002\uff09<\/p>\n","protected":false},"featured_media":5942,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[17],"class_list":["post-23011","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-17"],"acf":[],"taxonomy_info":{"product_category":[{"value":17,"label":"\u4e2d\u95f4\u4f53"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/03\/641571-10-0.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/23011","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/5942"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=23011"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=23011"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}