{"id":22598,"date":"2026-04-01T18:42:11","date_gmt":"2026-04-01T10:42:11","guid":{"rendered":"http:\/\/111.62.156.167\/index.php\/product\/tubastatin-a\/"},"modified":"2026-04-01T22:26:19","modified_gmt":"2026-04-01T14:26:19","slug":"tubastatin-a","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=tubastatin-a","title":{"rendered":"Tubastatin A"},"content":{"rendered":"<p>\u4ea7\u54c1\u8bf4\u660e<br \/>\n\u4ea7\u54c1\u8bf4\u660e<br \/>\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027<br \/>\nTubastatin A\uff08\u5316\u5b66\u540d\u79f0\uff1aN-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide\uff09\u662f\u4e00\u79cd\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0cCAS\u53f7\u4e3a1252003-15-8\uff0c\u5206\u5b50\u5f0f\u4e3aC20H21N3O2\uff0c\u5206\u5b50\u91cf\u4e3a371.861\u3002\u5176\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5177\u6709\u9ad8\u5ea6\u7684\u5316\u5b66\u7a33\u5b9a\u6027\u548c\u9009\u62e9\u6027\u3002\u8be5\u5316\u5408\u7269\u5c5e\u4e8e\u5f02\u7f9f\u809f\u9178\u7c7b\u884d\u751f\u7269\uff0c\u7ed3\u6784\u4e2d\u542b\u6709\u56db\u6c22\u5421\u5576\u5e76\u5432\u54da\u9aa8\u67b6\uff0c\u662f\u4e00\u79cd\u9ad8\u6548\u7684\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u6291\u5236\u5242\u3002<br \/>\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027<br \/>\nTubastatin A\u662f\u4e00\u79cd\u9009\u62e9\u6027HDAC6\u6291\u5236\u5242\uff0c\u5bf9HDAC6\u7684\u6291\u5236\u6d3b\u6027\u663e\u8457\u9ad8\u4e8e\u5176\u4ed6HDAC\u4e9a\u578b\uff08\u5982HDAC1\u3001HDAC4\u548cHDAC8\uff09\u3002\u5176IC50\u503c\u7ea6\u4e3a15 nM\uff0c\u8868\u73b0\u51fa\u4f18\u5f02\u7684\u9009\u62e9\u6027\u548c\u6548\u529b\u3002HDAC6\u5728\u7ec6\u80de\u8d28\u4e2d\u4e3b\u8981\u53c2\u4e0e\u5fae\u7ba1\u86cb\u767d\u7684\u53bb\u4e59\u9170\u5316\u8c03\u63a7\uff0c\u5f71\u54cd\u7ec6\u80de\u8fc1\u79fb\u3001\u86cb\u767d\u964d\u89e3\u548c\u514d\u75ab\u5e94\u7b54\u7b49\u8fc7\u7a0b\u3002Tubastatin A\u901a\u8fc7\u6291\u5236HDAC6\u6d3b\u6027\uff0c\u53ef\u589e\u52a0\u5fae\u7ba1\u86cb\u767d\u7684\u4e59\u9170\u5316\u6c34\u5e73\uff0c\u4ece\u800c\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u764c\u75c7\u548c\u708e\u75c7\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002<br \/>\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014<br \/>\nTubastatin A\u5e7f\u6cdb\u5e94\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7814\u7a76\u9886\u57df\uff0c\u7279\u522b\u662f\u5728\u795e\u7ecf\u79d1\u5b66\u3001\u80bf\u7624\u5b66\u548c\u514d\u75ab\u5b66\u7814\u7a76\u4e2d\u3002\u5177\u4f53\u7528\u9014\u5305\u62ec\uff1a<br \/>\n&#8211; \u7814\u7a76HDAC6\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u5e15\u91d1\u68ee\u75c5\uff09\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u3002<br \/>\n&#8211; \u63a2\u7d22HDAC6\u6291\u5236\u5242\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\uff0c\u5c24\u5176\u662f\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u548c\u767d\u8840\u75c5\u3002<br \/>\n&#8211; \u4f5c\u4e3a\u5de5\u5177\u5316\u5408\u7269\uff0c\u7528\u4e8e\u7814\u7a76\u7ec6\u80de\u8fc1\u79fb\u3001\u86cb\u767d\u805a\u96c6\u548c\u514d\u75ab\u8c03\u8282\u7b49\u751f\u7269\u5b66\u8fc7\u7a0b\u3002<br \/>\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae<br \/>\n\u672c\u54c1\u5e94\u50a8\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u4ee5\u786e\u4fdd\u7a33\u5b9a\u6027\u3002\u4f7f\u7528\u65f6\u5efa\u8bae\u5c06\u7c89\u672b\u6eb6\u89e3\u4e8eDMSO\u6216\u5176\u4ed6\u9002\u5f53\u6eb6\u5242\u4e2d\uff0c\u914d\u5236\u6210\u6bcd\u6db2\u540e\u8fdb\u4e00\u6b65\u7a00\u91ca\u81f3\u5de5\u4f5c\u6d53\u5ea6\u3002\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u88c5\u5907\uff0c\u907f\u514d\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u6216\u773c\u775b\u3002<br \/>\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f<br \/>\n\u672c\u4ea7\u54c1\u7ecfHPLC\u68c0\u6d4b\u786e\u8ba4\u7eaf\u5ea6\u9ad8\u4e8e96%\uff0c\u5e76\u63d0\u4f9b\u76f8\u5173\u5206\u6790\u8bc1\u4e66\u3002Tubastatin A\u5c5e\u4e8e\u5b9e\u9a8c\u7528\u5316\u5b66\u54c1\uff0c\u4ec5\u9650\u79d1\u7814\u4f7f\u7528\uff0c\u4e0d\u53ef\u7528\u4e8e\u4eba\u4f53\u6216\u4e34\u5e8a\u6cbb\u7597\u3002\u4f7f\u7528\u65f6\u9700\u9075\u5b88\u5b9e\u9a8c\u5ba4\u5b89\u5168\u89c4\u8303\uff0c\u59a5\u5584\u5904\u7406\u5e9f\u5f03\u7269\u3002\u5982\u9700\u8fdb\u4e00\u6b65\u6bd2\u7406\u5b66\u6570\u636e\uff0c\u8bf7\u53c2\u8003\u6750\u6599\u5b89\u5168\u6570\u636e\u8868\uff08MSDS\uff09\u3002<\/p>\n","protected":false},"featured_media":1397,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[17],"class_list":["post-22598","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-17"],"acf":[],"taxonomy_info":{"product_category":[{"value":17,"label":"\u4e2d\u95f4\u4f53"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/03\/1252003-15-8.jpg",464,464,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/22598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/1397"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=22598"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=22598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}