{"id":130040,"date":"2026-05-07T22:32:36","date_gmt":"2026-05-07T14:32:36","guid":{"rendered":"http:\/\/111.62.156.167\/?chemical-product=%e9%a9%ac%e6%9d%a5%e9%85%b0%e4%ba%9a%e8%83%ba%e5%9f%ba%e5%b7%b1%e9%85%b0-%e5%8d%95%e7%94%b2%e5%9f%ba%e6%be%b3%e7%91%9e%e4%bb%96%e6%b1%80-e"},"modified":"2026-05-07T22:32:36","modified_gmt":"2026-05-07T14:32:36","slug":"%e9%a9%ac%e6%9d%a5%e9%85%b0%e4%ba%9a%e8%83%ba%e5%9f%ba%e5%b7%b1%e9%85%b0-%e5%8d%95%e7%94%b2%e5%9f%ba%e6%be%b3%e7%91%9e%e4%bb%96%e6%b1%80-e","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=%e9%a9%ac%e6%9d%a5%e9%85%b0%e4%ba%9a%e8%83%ba%e5%9f%ba%e5%b7%b1%e9%85%b0-%e5%8d%95%e7%94%b2%e5%9f%ba%e6%be%b3%e7%91%9e%e4%bb%96%e6%b1%80-e","title":{"rendered":"\u9a6c\u6765\u9170\u4e9a\u80fa\u57fa\u5df1\u9170-\u5355\u7532\u57fa\u6fb3\u745e\u4ed6\u6c40 E"},"content":{"rendered":"<p>\u4ea7\u54c1\u8bf4\u660e<br \/>\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027<br \/>\n\u9a6c\u6765\u9170\u4e9a\u80fa\u57fa\u5df1\u9170-\u5355\u7532\u57fa\u6fb3\u745e\u4ed6\u6c40E\uff08Maleimidocaproyl-monomethylauristatin E\uff0c\u7b80\u79f0MC-MMAE\uff09\u662f\u4e00\u79cd\u9ad8\u7eaf\u5ea6\u5408\u6210\u5316\u5408\u7269\uff0c\u5316\u5b66\u5f0f\u4e3aC49H78N6O10\uff0c\u5206\u5b50\u91cf\u4e3a911.178\uff0cCAS\u53f7\u4e3a863971-24-8\u3002\u8be5\u4ea7\u54c1\u4ee5\u767d\u8272\u81f3\u7c7b\u767d\u8272\u56fa\u4f53\u5f62\u5f0f\u5b58\u5728\uff0c\u7eaf\u5ea6\u226596%\uff0c\u5c5e\u4e8e\u6fb3\u745e\u4ed6\u6c40\u7c7b\u5fae\u7ba1\u86cb\u767d\u6291\u5236\u5242\u884d\u751f\u7269\u3002\u5176\u7ed3\u6784\u5305\u542b\u9a6c\u6765\u9170\u4e9a\u80fa\u57fa\u56e2\uff0c\u53ef\u901a\u8fc7\u8fc8\u514b\u5c14\u52a0\u6210\u53cd\u5e94\u4e0e\u5def\u57fa\uff08-SH\uff09\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u786b\u919a\u952e\uff0c\u8fd9\u4e00\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\u5f00\u53d1\u4e2d\u7684\u5173\u952e\u8fde\u63a5\u5b50-\u8f7d\u8377\u5206\u5b50\u3002<br \/>\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027<br \/>\nMC-MMAE\u901a\u8fc7\u6291\u5236\u5fae\u7ba1\u86cb\u767d\u805a\u5408\uff0c\u963b\u65ad\u7ec6\u80de\u6709\u4e1d\u5206\u88c2\uff0c\u6700\u7ec8\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u51cb\u4ea1\u3002\u4f5c\u4e3aADC\u7684\u6838\u5fc3\u6bd2\u6027\u8f7d\u8377\uff0c\u5176\u6548\u529b\u53ef\u8fbe\u76ae\u6469\u5c14\u7ea7\u522b\u3002\u9a6c\u6765\u9170\u4e9a\u80fa\u57fa\u56e2\u8d4b\u4e88\u5176\u4e0e\u6297\u4f53\u94fe\u95f4\u4e8c\u786b\u952e\u5b9a\u5411\u5076\u8054\u7684\u80fd\u529b\uff0c\u663e\u8457\u63d0\u9ad8ADC\u7684\u9776\u5411\u6027\u548c\u7a33\u5b9a\u6027\u3002\u8be5\u5206\u5b50\u5728\u764c\u75c7\u6cbb\u7597\u9886\u57df\u5177\u6709\u91cd\u8981\u4ef7\u503c\uff0c\u5c24\u5176\u5728\u6dcb\u5df4\u7624\u3001\u4e73\u817a\u764c\u7b49\u5b9e\u4f53\u7624\u7684\u9776\u5411\u7597\u6cd5\u5f00\u53d1\u4e2d\u5e94\u7528\u5e7f\u6cdb\u3002<br \/>\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014<br \/>\nMC-MMAE\u4e3b\u8981\u7528\u4e8eADC\u836f\u7269\u7684\u7814\u53d1\u4e0e\u751f\u4ea7\uff0c\u5178\u578b\u5e94\u7528\u5305\u62ec\uff1a<br \/>\n&#8211; \u4e0e\u6297CD30\u3001HER2\u7b49\u9776\u70b9\u7684\u6297\u4f53\u5076\u8054\uff0c\u6784\u5efa\u4e34\u5e8a\u7ea7ADC\uff08\u5982Brentuximab vedotin\u7c7b\u4f3c\u7269\uff09<br \/>\n&#8211; \u4f5c\u4e3a\u5de5\u5177\u5206\u5b50\uff0c\u7528\u4e8e\u8bc4\u4f30\u65b0\u578b\u8fde\u63a5\u5b50\u6280\u672f\u7684\u7a33\u5b9a\u6027\u4e0e\u91ca\u653e\u6548\u7387<br \/>\n&#8211; \u5728\u80bf\u7624\u836f\u7406\u7814\u7a76\u4e2d\u4f5c\u4e3a\u9633\u6027\u5bf9\u7167\uff0c\u9a8c\u8bc1\u5fae\u7ba1\u6291\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236<br \/>\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae<br \/>\n\u4ea7\u54c1\u9700\u907f\u5149\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u5f00\u5c01\u540e\u5efa\u8bae\u5206\u88c5\u4ee5\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u4f7f\u7528\u65f6\u9700\u5728\u60f0\u6027\u6c14\u4f53\uff08\u5982\u6c2e\u6c14\uff09\u4fdd\u62a4\u4e0b\u64cd\u4f5c\uff0c\u6eb6\u89e3\u63a8\u8350\u4f7f\u7528\u65e0\u6c34DMSO\u6216DMF\u3002\u5de5\u4f5c\u6d53\u5ea6\u5e94\u6839\u636e\u5177\u4f53\u5b9e\u9a8c\u4f53\u7cfb\u4f18\u5316\uff0c\u5efa\u8bae\u521d\u59cb\u6d4b\u8bd5\u8303\u56f4\u4e3a0.1-10 nM\u3002\u6ce8\u610f\uff1a\u9a6c\u6765\u9170\u4e9a\u80fa\u57fa\u56e2\u5728pH>7.5\u6761\u4ef6\u4e0b\u6613\u6c34\u89e3\uff0c\u5076\u8054\u53cd\u5e94\u5e94\u5728pH 6.5-7.5\u7f13\u51b2\u4f53\u7cfb\u4e2d\u8fdb\u884c\u3002<br \/>\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f<br \/>\n\u672c\u4ea7\u54c1\u7ecfHPLC\u3001MS\u53caNMR\u4e25\u683c\u9a8c\u8bc1\uff0c\u7b26\u5408\u836f\u7269\u7814\u53d1\u7ea7\u6807\u51c6\u3002\u5b89\u5168\u6570\u636e\u5982\u4e0b\uff1a<br \/>\n&#8211; \u5371\u5bb3\u58f0\u660e\uff1aH301-H315-H319-H335\uff08\u541e\u54bd\u6709\u6bd2\uff0c\u9020\u6210\u76ae\u80a4\/\u773c\u775b\u523a\u6fc0\uff0c\u53ef\u80fd\u81f4\u547c\u5438\u9053\u523a\u6fc0\uff09<br \/>\n&#8211; \u9632\u62a4\u63aa\u65bd\uff1a\u4f69\u6234\u62a4\u76ee\u955c\u3001\u9632\u6e17\u900f\u624b\u5957\uff0c\u5728\u901a\u98ce\u6a71\u4e2d\u64cd\u4f5c<br \/>\n&#8211; \u5e9f\u5f03\u5904\u7406\uff1a\u6309\u5371\u9669\u5316\u5b66\u54c1\u89c4\u8303\u5904\u7f6e\uff0c\u4e0d\u53ef\u76f4\u63a5\u6392\u5165\u4e0b\u6c34\u9053<\/p>\n","protected":false},"featured_media":88793,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[32],"class_list":["post-130040","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-32"],"acf":[],"taxonomy_info":{"product_category":[{"value":32,"label":"\u751f\u5316\u8bd5\u5242"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/863971-24-8.jpg",364,364,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/130040","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/88793"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=130040"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=130040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}