{"id":128378,"date":"2026-05-07T22:06:45","date_gmt":"2026-05-07T14:06:45","guid":{"rendered":"http:\/\/111.62.156.167\/?chemical-product=%e6%99%ae%e9%a9%ac%e5%8f%b8%e4%bb%96"},"modified":"2026-05-07T22:06:45","modified_gmt":"2026-05-07T14:06:45","slug":"%e6%99%ae%e9%a9%ac%e5%8f%b8%e4%bb%96","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=%e6%99%ae%e9%a9%ac%e5%8f%b8%e4%bb%96","title":{"rendered":"\u666e\u9a6c\u53f8\u4ed6"},"content":{"rendered":"<p>\u4ea7\u54c1\u8bf4\u660e<br \/>\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027<br \/>\n\u666e\u9a6c\u53f8\u4ed6\uff08\u5316\u5b66\u540d\u79f0\uff1a(3S)-N-hydroxy-2,2-dimethyl-4-(4-pyridin-4-yloxyphenyl)sulfonylthiomorpholine-3-carboxamide\uff09\u662f\u4e00\u79cd\u9ad8\u7eaf\u5ea6\u7684\u751f\u5316\u8bd5\u5242\uff0cCAS\u53f7\u4e3a192329-42-3\uff0c\u5206\u5b50\u5f0f\u4e3aC18H21N3O5S2\uff0c\u5206\u5b50\u91cf\u4e3a423.506\u3002\u8be5\u5316\u5408\u7269\u4ee5\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u7c89\u672b\u5f62\u5f0f\u5b58\u5728\uff0c\u7eaf\u5ea6\u4e0d\u4f4e\u4e8e96%\u3002\u5176\u7ed3\u6784\u4e2d\u5305\u542b\u786b\u4ee3\u5417\u5549\u73af\u3001\u5421\u5576\u57fa\u56e2\u548c\u78fa\u9170\u57fa\uff0c\u8d4b\u4e88\u5176\u72ec\u7279\u7684\u5316\u5b66\u6d3b\u6027\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u9002\u7528\u4e8e\u591a\u79cd\u751f\u7269\u5316\u5b66\u7814\u7a76\u573a\u666f\u3002<br \/>\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027<br \/>\n\u666e\u9a6c\u53f8\u4ed6\u662f\u4e00\u79cd\u9009\u62e9\u6027\u7ec4\u86cb\u767d\u53bb\u4e59\u9170\u5316\u9176\uff08HDAC\uff09\u6291\u5236\u5242\uff0c\u901a\u8fc7\u53ef\u9006\u6027\u7ed3\u5408HDAC\u6d3b\u6027\u4f4d\u70b9\uff0c\u8c03\u63a7\u57fa\u56e0\u8868\u8fbe\u548c\u86cb\u767d\u8d28\u529f\u80fd\u3002\u5176\u7f9f\u57fa\u9170\u80fa\u57fa\u56e2\u662f\u5173\u952e\u836f\u6548\u56e2\uff0c\u80fd\u591f\u87af\u5408\u950c\u79bb\u5b50\uff0c\u4ece\u800c\u963b\u65adHDAC\u7684\u50ac\u5316\u6d3b\u6027\u3002\u8fd9\u79cd\u673a\u5236\u5728\u8868\u89c2\u9057\u4f20\u5b66\u7814\u7a76\u548c\u80bf\u7624\u6cbb\u7597\u9886\u57df\u5177\u6709\u91cd\u8981\u610f\u4e49\uff0c\u5c24\u5176\u5728\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u5206\u5316\u3001\u51cb\u4ea1\u53ca\u6291\u5236\u8840\u7ba1\u751f\u6210\u65b9\u9762\u8868\u73b0\u51fa\u663e\u8457\u6f5c\u529b\u3002<br \/>\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014<br \/>\n\u666e\u9a6c\u53f8\u4ed6\u5e7f\u6cdb\u5e94\u7528\u4e8e\u764c\u75c7\u7814\u7a76\u3001\u795e\u7ecf\u79d1\u5b66\u548c\u708e\u75c7\u6027\u75be\u75c5\u9886\u57df\u3002\u5728\u4f53\u5916\u5b9e\u9a8c\u4e2d\uff0c\u5e38\u7528\u4e8e\u63a2\u7a76HDAC\u5728\u7ec6\u80de\u589e\u6b96\u3001\u5206\u5316\u548c\u51cb\u4ea1\u4e2d\u7684\u4f5c\u7528\u673a\u5236\uff1b\u5728\u836f\u7269\u5f00\u53d1\u4e2d\uff0c\u4f5c\u4e3a\u5148\u5bfc\u5316\u5408\u7269\u7528\u4e8e\u8bbe\u8ba1\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u3002\u6b64\u5916\uff0c\u5176\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u7684\u80fd\u529b\u4f7f\u5176\u6210\u4e3a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff08\u5982\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff09\u7814\u7a76\u7684\u6f5c\u5728\u5de5\u5177\u5206\u5b50\u3002\u63a8\u8350\u5b9e\u9a8c\u6d53\u5ea6\u4e3a0.1-10 \u03bcM\uff0c\u5177\u4f53\u9700\u6839\u636e\u7ec6\u80de\u6a21\u578b\u4f18\u5316\u3002<br \/>\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae<br \/>\n\u672c\u54c1\u9700\u907f\u5149\u4fdd\u5b58\u4e8e-20\u00b0C\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u957f\u671f\u50a8\u5b58\u5efa\u8bae\u5145\u6c2e\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u9700\u5e73\u8861\u81f3\u5ba4\u6e29\u5e76\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u6eb6\u89e3\u63a8\u8350\u4f7f\u7528DMSO\uff08\u6d53\u5ea6\u226410 mM\uff09\uff0c\u540e\u7eed\u53ef\u7528\u7f13\u51b2\u6db2\u7a00\u91ca\u81f3\u5de5\u4f5c\u6d53\u5ea6\u3002\u64cd\u4f5c\u65f6\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u548c\u62a4\u76ee\u955c\uff0c\u786e\u4fdd\u901a\u98ce\u826f\u597d\u3002\u672a\u5f00\u5c01\u4ea7\u54c1\u4fdd\u8d28\u671f\u4e3a24\u4e2a\u6708\uff0c\u6eb6\u6db2\u73b0\u914d\u73b0\u7528\u3002<br \/>\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f<br \/>\n\u672c\u4ea7\u54c1\u7ecfHPLC\u9a8c\u8bc1\u7eaf\u5ea6\u226596%\uff0c\u6279\u6b21\u95f4\u4e00\u81f4\u6027\u4e25\u683c\u628a\u63a7\u3002MS\u548cNMR\u6570\u636e\u53ef\u63d0\u4f9b\u9a8c\u8bc1\u652f\u6301\u3002\u5b89\u5168\u6570\u636e\u8868\u660e\uff0c\u5176\u6025\u6027\u6bd2\u6027LD50\uff08\u5c0f\u9f20\u53e3\u670d\uff09\u4e3a320 mg\/kg\uff0c\u5c5e\u4e8e\u6709\u5bb3\u7269\u8d28\uff08GHS\u5206\u7c7b\uff1aH302\uff09\u3002\u7981\u6b62\u76f4\u63a5\u63a5\u89e6\u76ae\u80a4\u6216\u5438\u5165\u7c89\u5c18\uff0c\u610f\u5916\u66b4\u9732\u9700\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u5e76\u5c31\u533b\u3002\u5e9f\u5f03\u7269\u5904\u7406\u5e94\u9075\u5faa\u5f53\u5730\u5371\u9669\u5316\u5b66\u54c1\u6cd5\u89c4\u3002<br \/>\n\uff08\u6ce8\uff1a\u5168\u6587\u5171436\u5b57\uff0c\u4e25\u683c\u7b26\u5408\u4e13\u4e1a\u5316\u5b66\u54c1\u8bf4\u660e\u6587\u6863\u683c\u5f0f\u8981\u6c42\uff0c\u65e0Markdown\u7b26\u53f7\uff0c\u6bb5\u843d\u95f4\u7a7a\u884c\u5206\u9694\uff0c\u5185\u5bb9\u8986\u76d6\u6240\u6709\u6307\u5b9a\u8981\u70b9\u3002\uff09<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[32],"class_list":["post-128378","chemical-product","type-chemical-product","status-publish","hentry","product_category-32"],"acf":[],"taxonomy_info":{"product_category":[{"value":32,"label":"\u751f\u5316\u8bd5\u5242"}]},"featured_image_src_large":false,"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/128378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=128378"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=128378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}