{"id":118036,"date":"2026-05-07T19:03:00","date_gmt":"2026-05-07T11:03:00","guid":{"rendered":"http:\/\/111.62.156.167\/?chemical-product=2-4-4455-tetramethyl-132-dioxaborolan-2-ylpyrazol-1-ylacetonitrile"},"modified":"2026-05-07T19:03:00","modified_gmt":"2026-05-07T11:03:00","slug":"2-4-4455-tetramethyl-132-dioxaborolan-2-ylpyrazol-1-ylacetonitrile","status":"publish","type":"chemical-product","link":"https:\/\/bio-get.com\/?chemical-product=2-4-4455-tetramethyl-132-dioxaborolan-2-ylpyrazol-1-ylacetonitrile","title":{"rendered":"2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetonitrile"},"content":{"rendered":"

\u4ea7\u54c1\u8bf4\u660e
\n2-[4-(4,4,5,5-\u56db\u7532\u57fa-1,3,2-\u4e8c\u6c27\u787c\u6742\u73af\u620a\u70f7-2-\u57fa)\u5421\u5511-1-\u57fa]\u4e59\u8148\u4ea7\u54c1\u8bf4\u660e
\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n\u672c\u4ea7\u54c1\u4e3a\u767d\u8272\u81f3\u7c7b\u767d\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u5316\u5b66\u540d\u79f0\u4e3a2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]acetonitrile\uff0c\u5206\u5b50\u5f0fC11H16BN3O2\uff0c\u5206\u5b50\u91cf233.075\uff0cCAS\u53f71093307-35-7\u3002\u5176\u7ed3\u6784\u4e2d\u5305\u542b\u5421\u5511\u73af\u4e0e\u4e8c\u6c27\u787c\u6742\u73af\u620a\u70f7\u57fa\u56e2\uff0c\u901a\u8fc7\u4e59\u8148\u8fde\u63a5\uff0c\u5f62\u6210\u7a33\u5b9a\u7684\u787c\u9178\u916f\u884d\u751f\u7269\u3002\u7eaf\u5ea6\u226596%\uff0c\u53ef\u901a\u8fc7HPLC\u548cNMR\u9a8c\u8bc1\u3002\u8be5\u5316\u5408\u7269\u5728\u5e38\u6e29\u4e0b\u7a33\u5b9a\uff0c\u6613\u6eb6\u4e8e\u6709\u673a\u6eb6\u5242\u5982DMSO\u3001\u7532\u9187\u548c\u4e59\u8148\uff0c\u5fae\u6eb6\u4e8e\u6c34\u3002
\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n\u4f5c\u4e3a\u787c\u9178\u916f\u7c7b\u5316\u5408\u7269\uff0c\u8be5\u4ea7\u54c1\u5728Suzuki-Miyaura\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u9ad8\u53cd\u5e94\u6d3b\u6027\uff0c\u53ef\u4f5c\u4e3a\u5173\u952e\u4e2d\u95f4\u4f53\u7528\u4e8e\u6784\u5efa\u78b3-\u78b3\u952e\u3002\u5176\u5421\u5511\u57fa\u56e2\u8d4b\u4e88\u5206\u5b50\u826f\u597d\u7684\u914d\u4f4d\u80fd\u529b\uff0c\u800c\u787c\u9178\u916f\u90e8\u5206\u5728\u6e29\u548c\u6761\u4ef6\u4e0b\u53ef\u6c34\u89e3\u4e3a\u787c\u9178\uff0c\u8fdb\u4e00\u6b65\u53c2\u4e0e\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u3002\u5728\u836f\u7269\u5316\u5b66\u4e2d\uff0c\u6b64\u7c7b\u7ed3\u6784\u5e38\u7528\u4e8e\u9776\u5411\u86cb\u767d\u6fc0\u9176\u7684\u6291\u5236\u5242\u8bbe\u8ba1\uff0c\u5c24\u5176\u5728\u6297\u764c\u548c\u6297\u708e\u836f\u7269\u7814\u53d1\u4e2d\u5177\u6709\u91cd\u8981\u4ef7\u503c\u3002
\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u8be5\u4ea7\u54c1\u4e3b\u8981\u5e94\u7528\u4e8e\u533b\u836f\u7814\u53d1\u548c\u6709\u673a\u5408\u6210\u9886\u57df\u3002\u5177\u4f53\u7528\u9014\u5305\u62ec\uff1a\u4f5c\u4e3a\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7684\u6838\u5fc3\u9aa8\u67b6\uff0c\u7528\u4e8e\u6fc0\u9176\u6291\u5236\u5242\uff08\u5982EGFR\u3001ALK\u7b49\uff09\u7684\u7ed3\u6784\u4f18\u5316\uff1b\u5728PET\u663e\u5f71\u5242\u5408\u6210\u4e2d\u4f5c\u4e3a\u787c\u9178\u524d\u4f53\uff1b\u6b64\u5916\uff0c\u8fd8\u53ef\u7528\u4e8e\u6750\u6599\u79d1\u5b66\u4e2d\u529f\u80fd\u5316\u805a\u5408\u7269\u7684\u5236\u5907\u3002\u5176\u9ad8\u7eaf\u5ea6\u7279\u6027\u4f7f\u5176\u7279\u522b\u9002\u5408\u9ad8\u901a\u91cf\u7b5b\u9009\u548c\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb\uff08SAR\uff09\u7814\u7a76\u3002
\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u5728-20\u00b0C\u3001\u5e72\u71e5\u907f\u5149\u6761\u4ef6\u4e0b\u957f\u671f\u50a8\u5b58\uff0c\u77ed\u671f\u4f7f\u7528\u53ef\u7f6e\u4e8e4\u00b0C\u73af\u5883\u3002\u5f00\u5c01\u540e\u9700\u5145\u60f0\u6027\u6c14\u4f53\uff08\u5982\u6c2e\u6c14\uff09\u4fdd\u62a4\u4ee5\u907f\u514d\u5438\u6e7f\u3002\u4f7f\u7528\u65f6\u5e94\u5728\u60f0\u6027\u6c14\u6c1b\uff08\u6c29\u6c14\/\u6c2e\u6c14\uff09\u4e0b\u64cd\u4f5c\uff0c\u6eb6\u89e3\u63a8\u8350\u4f7f\u7528\u65e0\u6c34DMSO\u3002\u907f\u514d\u4e0e\u5f3a\u6c27\u5316\u5242\u6216\u9178\u78b1\u63a5\u89e6\uff0c\u4ee5\u9632\u787c\u9178\u916f\u952e\u65ad\u88c2\u3002
\n5. \u8d28\u91cf\u63a7\u5236\u4e0e\u5b89\u5168\u4fe1\u606f
\n\u672c\u4ea7\u54c1\u7ecf\u4e25\u683c\u8d28\u63a7\uff0c\u5305\u62ecHPLC\u7eaf\u5ea6\u68c0\u6d4b\u3001\u8d28\u8c31\u548c\u6838\u78c1\u5171\u632f\u8c31\u9a8c\u8bc1\u3002\u5b89\u5168\u6570\u636e\u8868\u660e\uff0c\u5176LD50\uff08\u5927\u9f20\u53e3\u670d\uff09>500 mg\/kg\uff0c\u4f46\u4ecd\u9700\u9075\u5b88\u5b9e\u9a8c\u5ba4\u5b89\u5168\u89c4\u8303\uff1a\u64cd\u4f5c\u65f6\u4f69\u6234\u9632\u62a4\u624b\u5957\u548c\u62a4\u76ee\u955c\uff0c\u907f\u514d\u5438\u5165\u7c89\u5c18\u6216\u63a5\u89e6\u76ae\u80a4\u3002\u5982\u610f\u5916\u63a5\u89e6\uff0c\u7acb\u5373\u7528\u5927\u91cf\u6e05\u6c34\u51b2\u6d17\u5e76\u5c31\u533b\u3002\u5e9f\u5f03\u7269\u9700\u6309\u5371\u9669\u5316\u5b66\u54c1\u5904\u7406\u6cd5\u89c4\u5904\u7f6e\u3002
\n\u6ce8\uff1a\u4ee5\u4e0a\u4fe1\u606f\u57fa\u4e8e\u73b0\u6709\u7814\u7a76\u6570\u636e\uff0c\u5177\u4f53\u5e94\u7528\u9700\u7ed3\u5408\u5b9e\u9a8c\u6761\u4ef6\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n","protected":false},"featured_media":76425,"template":"","meta":{"_acf_changed":false,"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":""},"product_category":[32],"class_list":["post-118036","chemical-product","type-chemical-product","status-publish","has-post-thumbnail","hentry","product_category-32"],"acf":[],"taxonomy_info":{"product_category":[{"value":32,"label":"\u751f\u5316\u8bd5\u5242"}]},"featured_image_src_large":["https:\/\/bio-get.com\/wp-content\/uploads\/2026\/04\/1093307-35-7.jpg",364,364,false],"author_info":[],"comment_info":"","_links":{"self":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product\/118036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/chemical-product"}],"about":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/types\/chemical-product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=\/wp\/v2\/media\/76425"}],"wp:attachment":[{"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=118036"}],"wp:term":[{"taxonomy":"product_category","embeddable":true,"href":"https:\/\/bio-get.com\/index.php?rest_route=%2Fwp%2Fv2%2Fproduct_category&post=118036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}