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\u4ea7\u54c1\u8bf4\u660e
\n(S)-\u68c9\u915a\u4e59\u9178\u4ea7\u54c1\u8bf4\u660e
\n1. \u4ea7\u54c1\u6982\u8ff0\u4e0e\u5316\u5b66\u7279\u6027
\n(S)-\u68c9\u915a\u4e59\u9178\uff08(S)-Gossypol acetic acid\uff09\u662f\u4e00\u79cd\u5929\u7136\u591a\u915a\u5316\u5408\u7269\u7684\u65cb\u5149\u5f02\u6784\u4f53\uff0c\u5316\u5b66\u5f0f\u4e3aC32H34O10\uff0c\u5206\u5b50\u91cf\u4e3a578.606\uff0cCAS\u53f7\u4e3a1189561-66-7\u3002\u672c\u54c1\u4e3a\u9ec4\u8272\u81f3\u68d5\u8272\u7ed3\u6676\u6027\u7c89\u672b\uff0c\u7eaf\u5ea6\u226596%\uff0c\u6613\u6eb6\u4e8e\u4e8c\u7532\u57fa\u4e9a\u781c\uff08DMSO\uff09\u548c\u90e8\u5206\u6709\u673a\u6eb6\u5242\uff0c\u5fae\u6eb6\u4e8e\u6c34\u3002\u5176\u7ed3\u6784\u4e2d\u542b\u6709\u591a\u4e2a\u915a\u7f9f\u57fa\u548c\u919b\u57fa\uff0c\u5177\u6709\u663e\u8457\u7684\u6297\u6c27\u5316\u6027\u548c\u624b\u6027\u7279\u5f81\uff0c\u662f\u68c9\u915a\uff08Gossypol\uff09\u7684\u5de6\u65cb\u5f02\u6784\u4f53\u884d\u751f\u7269\u3002
\n2. \u751f\u7269\u5316\u5b66\u529f\u80fd\u4e0e\u91cd\u8981\u6027
\n(S)-\u68c9\u915a\u4e59\u9178\u662f\u68c9\u915a\u7684\u6d3b\u6027\u5f62\u5f0f\u4e4b\u4e00\uff0c\u901a\u8fc7\u7279\u5f02\u6027\u6291\u5236Bcl-2\u5bb6\u65cf\u86cb\u767d\uff08\u5982Bcl-xL\uff09\u53d1\u6325\u4fc3\u51cb\u4ea1\u4f5c\u7528\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u8868\u73b0\u51fa\u9009\u62e9\u6027\u6bd2\u6027\u3002\u4e0e\u6d88\u65cb\u68c9\u915a\u76f8\u6bd4\uff0c(S)-\u6784\u578b\u5177\u6709\u66f4\u9ad8\u7684\u751f\u7269\u6d3b\u6027\u548c\u8f83\u4f4e\u7684\u5168\u8eab\u6bd2\u6027\uff0c\u5728\u9776\u5411\u6cbb\u7597\u7814\u7a76\u4e2d\u5907\u53d7\u5173\u6ce8\u3002\u6b64\u5916\uff0c\u5b83\u8fd8\u53ef\u5e72\u6270\u7ebf\u7c92\u4f53\u529f\u80fd\uff0c\u5f71\u54cd\u80fd\u91cf\u4ee3\u8c22\u901a\u8def\uff0c\u5728\u6297\u75c5\u6bd2\u548c\u7537\u6027\u907f\u5b55\u9886\u57df\u4e5f\u6709\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002
\n3. \u4e3b\u8981\u5e94\u7528\u9886\u57df\u4e0e\u5177\u4f53\u7528\u9014
\n\u672c\u54c1\u4e3b\u8981\u7528\u4e8e\u751f\u7269\u533b\u5b66\u7814\u7a76\u9886\u57df\uff1a
\n– \u4f5c\u4e3a\u5c0f\u5206\u5b50\u6291\u5236\u5242\uff0c\u7528\u4e8e\u80bf\u7624\u51cb\u4ea1\u673a\u5236\u7814\u7a76\u53ca\u6297\u764c\u836f\u7269\u7b5b\u9009
\n– \u5728\u7537\u6027\u751f\u6b96\u751f\u7269\u5b66\u4e2d\u7528\u4e8e\u7cbe\u5b50\u53d1\u751f\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u7814\u7a76
\n– \u4f5c\u4e3a\u6807\u51c6\u54c1\u7528\u4e8e\u68c9\u915a\u5f02\u6784\u4f53\u7684\u8272\u8c31\u5206\u6790\u4e0e\u5b9a\u91cf\u68c0\u6d4b
\n– \u75c5\u6bd2\u5b66\u7814\u7a76\u4e2d\u7684\u75c5\u6bd2\u590d\u5236\u6291\u5236\u5242\u5f00\u53d1
\n4. \u50a8\u5b58\u6761\u4ef6\u4e0e\u4f7f\u7528\u5efa\u8bae
\n\u5efa\u8bae\u907f\u5149\u4fdd\u5b58\u4e8e-20\u2103\u5e72\u71e5\u73af\u5883\u4e2d\uff0c\u957f\u671f\u50a8\u5b58\u9700\u5145\u60f0\u6027\u6c14\u4f53\u4fdd\u62a4\u3002\u4f7f\u7528\u65f6\u9700\u5728\u60f0\u6027\u6c14\u6c1b\u4e0b\u64cd\u4f5c\uff0c\u907f\u514d\u53cd\u590d\u51bb\u878d\u3002\u914d\u5236\u6eb6\u6db2\u5efa\u8bae\u73b0\u914d\u73b0\u7528\uff0c\u6eb6\u5242\u4f18\u5148\u9009\u62e9DMSO\uff08\u6d53\u5ea6\u4e0d\u8d85\u8fc710mM\uff09\uff0c\u6c34\u6eb6\u6db2\u9700\u8d85\u58f0\u52a9\u6eb6\u5e76\u8c03\u8282pH\u81f3\u4e2d\u6027\u3002\u5b9e\u9a8c\u64cd\u4f5c\u9700\u4f69\u6234\u9632\u62a4\u624b\u5957\u53ca\u62a4\u76ee\u955c\u3002
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